High-frequency ventilation attenuation of hypoxic pulmonary vasoconstriction. The role of prostacyclin

R. C. Wetzel, J. B. Gordon, T. J. Gregory, F. R. Gioia, N. F. Adkinson, J. T. Sylvester

Research output: Contribution to journalArticle

Abstract

In order to determine the effects of high-frequency ventilation on the pulmonary vascular response to hypoxia, we assessed pulmonary vascular resistance at 2 levels of inspired oxygen tension (PI(O2)), 200 and 30 mmHg, during conventional and high-frequency ventilation in the isolated, blood-perfused lungs of 10 sheep, 5 treated with indomethacin (40 μg/ml of perfusate) and 5 untreated. Resistance was assessed by measuring pulmonary artery pressure-flow curves generated over a wide range of flows (20 to 140 ml·min-1·kg body wt-1). Conventional ventilation was provided by an animal ventilator at a rate of 10 min-1 and a tidal volume of 10 ml·kg body wt-1. High-frequency ventilation was provided by a flow interrupter at a rate of 1,200 min-1 and a tidal volume less than 1.5 ml·kg body wt-1. In the 5 untreated lungs, the normoxic pressure-flow curve was unaltered by high-frequency ventilation, but the hypoxic pulmonary vasoconstrictor response was significantly attenuated. Furthermore, the net rate of change of 6-keto-prostaglandin F(1α) concentration in the perfusate during hypoxia was significantly greater with high-frequency ventilation (65.4 ± 8.9 pg·ml-1·min-1) than with conventional ventilation (2.8 ± 18.7 pg·ml-1·min-1). In the 5 indomethacin-treated lungs, production of 6-keto-prostaglandin F(1α) was markedly depressed, and the attenuation of the hypoxic vasoconstrictor response by high-frequency ventilation was abolished. These results demonstrate that in isolated sheep lungs, high-frequency ventilation attenuated the pulmonary vascular response to hypoxia and suggest that this attenuation could be due to enhanced prostacyclin release by the lungs.

Original languageEnglish (US)
Pages (from-to)99-103
Number of pages5
JournalAmerican Review of Respiratory Disease
Volume132
Issue number1
StatePublished - Sep 19 1985

ASJC Scopus subject areas

  • Pulmonary and Respiratory Medicine

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    Wetzel, R. C., Gordon, J. B., Gregory, T. J., Gioia, F. R., Adkinson, N. F., & Sylvester, J. T. (1985). High-frequency ventilation attenuation of hypoxic pulmonary vasoconstriction. The role of prostacyclin. American Review of Respiratory Disease, 132(1), 99-103.