High frequency of G to a transition mutation in the stromal cell derived factor-1 gene in India, a chemokine that blocks HIV-1 (X4) infection: Multiple proteins bind to 3′-untranslated region of SDF-1 RNA

N. Ramamoorti, J. Kumarvelu, Shanmugasundara Ganapathy, K. Rani, A. C. Banerjea

Research output: Contribution to journalArticle

Abstract

It has become clear that mutations in a variety of host genes possess the ability to influence the progression of HIV-1, prominent among them are the chemokines. Stromal cell derived factor-1 (SDF-1), an α-chemokine, is a natural ligand for HIV-1 coreceptor-CXCR4 and a potent chemokine that blocks infection by X4 viruses. Nucleotide G to A transition (nucleotide position 801 with respect to the ATG initiation codon) in the 3′-untranslated region of SDF-1 RNA is implicated in having disease-modifying effects. We have screened 100 normal healthy individuals from north India where HIV-1 is spreading at an alarming rate. This mutation is present in 40% (40 out of 100) individuals, 32% being heterozygous and 8% being homozygous for this mutation. This mutation showed Mendelian inheritance in one of the families studied. This observation could be important in understanding the progression or pathogenesis of HIV-1 in India. We also show that multiple proteins bind in the 3′-untranslated region of the SDF-1 RNA.

Original languageEnglish (US)
Pages (from-to)408-410
Number of pages3
JournalGenes and Immunity
Volume2
Issue number7
DOIs
StatePublished - Nov 2001
Externally publishedYes

Fingerprint

Chemokine CXCL12
3' Untranslated Regions
Chemokines
HIV-1
India
RNA
Mutation
Infection
Genes
Proteins
Nucleotides
Initiator Codon
Virus Diseases
Ligands

Keywords

  • Chemokine
  • HIV
  • Pathogenesis

ASJC Scopus subject areas

  • Genetics
  • Immunology
  • Genetics(clinical)

Cite this

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title = "High frequency of G to a transition mutation in the stromal cell derived factor-1 gene in India, a chemokine that blocks HIV-1 (X4) infection: Multiple proteins bind to 3′-untranslated region of SDF-1 RNA",
abstract = "It has become clear that mutations in a variety of host genes possess the ability to influence the progression of HIV-1, prominent among them are the chemokines. Stromal cell derived factor-1 (SDF-1), an α-chemokine, is a natural ligand for HIV-1 coreceptor-CXCR4 and a potent chemokine that blocks infection by X4 viruses. Nucleotide G to A transition (nucleotide position 801 with respect to the ATG initiation codon) in the 3′-untranslated region of SDF-1 RNA is implicated in having disease-modifying effects. We have screened 100 normal healthy individuals from north India where HIV-1 is spreading at an alarming rate. This mutation is present in 40{\%} (40 out of 100) individuals, 32{\%} being heterozygous and 8{\%} being homozygous for this mutation. This mutation showed Mendelian inheritance in one of the families studied. This observation could be important in understanding the progression or pathogenesis of HIV-1 in India. We also show that multiple proteins bind in the 3′-untranslated region of the SDF-1 RNA.",
keywords = "Chemokine, HIV, Pathogenesis",
author = "N. Ramamoorti and J. Kumarvelu and Shanmugasundara Ganapathy and K. Rani and Banerjea, {A. C.}",
year = "2001",
month = "11",
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AU - Ramamoorti, N.

AU - Kumarvelu, J.

AU - Ganapathy, Shanmugasundara

AU - Rani, K.

AU - Banerjea, A. C.

PY - 2001/11

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N2 - It has become clear that mutations in a variety of host genes possess the ability to influence the progression of HIV-1, prominent among them are the chemokines. Stromal cell derived factor-1 (SDF-1), an α-chemokine, is a natural ligand for HIV-1 coreceptor-CXCR4 and a potent chemokine that blocks infection by X4 viruses. Nucleotide G to A transition (nucleotide position 801 with respect to the ATG initiation codon) in the 3′-untranslated region of SDF-1 RNA is implicated in having disease-modifying effects. We have screened 100 normal healthy individuals from north India where HIV-1 is spreading at an alarming rate. This mutation is present in 40% (40 out of 100) individuals, 32% being heterozygous and 8% being homozygous for this mutation. This mutation showed Mendelian inheritance in one of the families studied. This observation could be important in understanding the progression or pathogenesis of HIV-1 in India. We also show that multiple proteins bind in the 3′-untranslated region of the SDF-1 RNA.

AB - It has become clear that mutations in a variety of host genes possess the ability to influence the progression of HIV-1, prominent among them are the chemokines. Stromal cell derived factor-1 (SDF-1), an α-chemokine, is a natural ligand for HIV-1 coreceptor-CXCR4 and a potent chemokine that blocks infection by X4 viruses. Nucleotide G to A transition (nucleotide position 801 with respect to the ATG initiation codon) in the 3′-untranslated region of SDF-1 RNA is implicated in having disease-modifying effects. We have screened 100 normal healthy individuals from north India where HIV-1 is spreading at an alarming rate. This mutation is present in 40% (40 out of 100) individuals, 32% being heterozygous and 8% being homozygous for this mutation. This mutation showed Mendelian inheritance in one of the families studied. This observation could be important in understanding the progression or pathogenesis of HIV-1 in India. We also show that multiple proteins bind in the 3′-untranslated region of the SDF-1 RNA.

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KW - Pathogenesis

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