High frequency of false-positive hepatitis C virus enzyme-linked immunosorbent assay in Rakai, Uganda

Caroline E. Mullis, Oliver B. Laeyendecker, Steven James Reynolds, Ponsiano Ocama, Jeffrey Quinn, Iga Boaz, Ronald H Gray, Gregory D Kirk, David L Thomas, Thomas C Quinn, Lara Stabinski

Research output: Contribution to journalArticle

Abstract

The prevalence of hepatitis C virus (HCV) infection in sub-Saharan Africa remains unclear. We tested 1000 individuals from Rakai, Uganda, with the Ortho version 3.0 HCV enzyme-linked immunosorbent assay. All serologically positive samples were tested for HCV RNA. Seventy-six of the 1000 (7.6%) participants were HCV antibody positive; none were confirmed by detection of HCV RNA.

Original languageEnglish (US)
Pages (from-to)1747-1750
Number of pages4
JournalClinical Infectious Diseases
Volume57
Issue number12
DOIs
StatePublished - Dec 2013

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Uganda
Hepacivirus
Enzyme-Linked Immunosorbent Assay
RNA
Hepatitis C Antibodies
Africa South of the Sahara
Virus Diseases

Keywords

  • Africa
  • ELISA
  • hepatitis C virus

ASJC Scopus subject areas

  • Infectious Diseases
  • Microbiology (medical)

Cite this

High frequency of false-positive hepatitis C virus enzyme-linked immunosorbent assay in Rakai, Uganda. / Mullis, Caroline E.; Laeyendecker, Oliver B.; Reynolds, Steven James; Ocama, Ponsiano; Quinn, Jeffrey; Boaz, Iga; Gray, Ronald H; Kirk, Gregory D; Thomas, David L; Quinn, Thomas C; Stabinski, Lara.

In: Clinical Infectious Diseases, Vol. 57, No. 12, 12.2013, p. 1747-1750.

Research output: Contribution to journalArticle

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