High frequency of false-positive hepatitis C virus enzyme-linked immunosorbent assay in Rakai, Uganda

Caroline E. Mullis, Oliver Laeyendecker, Steven J. Reynolds, Ponsiano Ocama, Jeffrey Quinn, Iga Boaz, Ronald H. Gray, Gregory D. Kirk, David L. Thomas, Thomas C. Quinn, Lara Stabinski

Research output: Contribution to journalArticle

Abstract

The prevalence of hepatitis C virus (HCV) infection in sub-Saharan Africa remains unclear. We tested 1000 individuals from Rakai, Uganda, with the Ortho version 3.0 HCV enzyme-linked immunosorbent assay. All serologically positive samples were tested for HCV RNA. Seventy-six of the 1000 (7.6%) participants were HCV antibody positive; none were confirmed by detection of HCV RNA.

Original languageEnglish (US)
Pages (from-to)1747-1750
Number of pages4
JournalClinical Infectious Diseases
Volume57
Issue number12
DOIs
StatePublished - Dec 2013

Keywords

  • Africa
  • ELISA
  • hepatitis C virus

ASJC Scopus subject areas

  • Microbiology (medical)
  • Infectious Diseases

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