High field localized proton spectroscopy in small volumes: greatly improved localization and shimming using shielded strong gradients

Peter C.M. van Zijl, Chrit T.W. Moonen, Jeffry R. Alger, Jack S. Cohen, Scott A. Chesnick

Research output: Contribution to journalArticle


The availability of shielded gradients facilitates accurate single‐voxel localized spectroscopy. Exact localization (90−99%) of volumes as small as 2 × 2 × 2 mm is demonstrated using a modified stimulated echo sequence. Strong gradient pulses (up to 200 mT/m) are employed to clear the stimulated echo of unwanted magnetization, enabling superior (single‐scan) shimming of the selected volume. In vivo and in vitro proton NMR results at 4.7 T are presented. © 1989 Academic Press, Inc.

Original languageEnglish (US)
Pages (from-to)256-265
Number of pages10
JournalMagnetic resonance in medicine
Issue number2
StatePublished - May 1989


ASJC Scopus subject areas

  • Radiology Nuclear Medicine and imaging

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