Abstract
Prostate-specific membrane antigen (PSMA) is a transmembrane protein expressed in prostate cancer as well as in the neo-vasculature of nonprostatic solid tumors. Here, we determined the expression pattern of PSMA in the vasculature of oral squamous cell carcinoma. Using a previously validated antibody, PSMA staining distribution and cyclooxygenase 2 (COX2) expression status was evaluated in a cohort of patients with squamous cell carcinoma of the oral cavity (n=96) using immunohistochemistry and was correlated with clinicopathological features as well as outcome. Twenty-four (25%) cases showed no detectable PSMA staining, 48 (50%) demonstrated positive immunoreactivity for PSMA in less than 50% of microvessels and 24 (25%) cases showed strong endothelial PSMA expression in more than 50% of tumor-associated microvessels. High endothelial PSMA expression was associated with greatly reduced survival (18.2 vs 77.3 months; P=0.0001) and maintained prognostic significance after adjusting for grade and stage in multivariate analysis (hazard ratio=2.19, P=0.007). Furthermore, we observed a strong association between endothelial PSMA and cancer cell-specific COX2 expression. In conclusion, we provide the first evidence for the prognostic significance of endothelial PSMA expression in oral squamous cell carcinoma and, suggest a potential interaction between arachidonic acid metabolites and endothelial PSMA expression in the tumor neo-vasculature.
| Original language | English (US) |
|---|---|
| Pages (from-to) | 1079-1085 |
| Number of pages | 7 |
| Journal | Modern Pathology |
| Volume | 25 |
| Issue number | 8 |
| DOIs | |
| State | Published - Aug 2012 |
| Externally published | Yes |
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Keywords
- COX2
- FOLH1
- oral squamous cell carcinoma
- prognosis
- prostate-specific membrane antigen
- PSMA
- vasculature
ASJC Scopus subject areas
- Pathology and Forensic Medicine
Cite this
High expression of prostate-specific membrane antigen in the tumor-associated neo-vasculature is associated with worse prognosis in squamous cell carcinoma of the oral cavity. / Haffner, Michael C.; Laimer, Johannes; Chaux, Alcides; Schäfer, Georg; Obrist, Peter; Brunner, Andrea; Kronberger, Irmgard E.; Laimer, Klaus; Gurel, Bora; Koller, Johann Benedikt; Seifarth, Christof; Zelger, Bettina; Klocker, Helmut; Rasse, Michael; Doppler, Wolfgang; Bander, Neil H.
In: Modern Pathology, Vol. 25, No. 8, 08.2012, p. 1079-1085.Research output: Contribution to journal › Article
}
TY - JOUR
T1 - High expression of prostate-specific membrane antigen in the tumor-associated neo-vasculature is associated with worse prognosis in squamous cell carcinoma of the oral cavity
AU - Haffner, Michael C.
AU - Laimer, Johannes
AU - Chaux, Alcides
AU - Schäfer, Georg
AU - Obrist, Peter
AU - Brunner, Andrea
AU - Kronberger, Irmgard E.
AU - Laimer, Klaus
AU - Gurel, Bora
AU - Koller, Johann Benedikt
AU - Seifarth, Christof
AU - Zelger, Bettina
AU - Klocker, Helmut
AU - Rasse, Michael
AU - Doppler, Wolfgang
AU - Bander, Neil H.
PY - 2012/8
Y1 - 2012/8
N2 - Prostate-specific membrane antigen (PSMA) is a transmembrane protein expressed in prostate cancer as well as in the neo-vasculature of nonprostatic solid tumors. Here, we determined the expression pattern of PSMA in the vasculature of oral squamous cell carcinoma. Using a previously validated antibody, PSMA staining distribution and cyclooxygenase 2 (COX2) expression status was evaluated in a cohort of patients with squamous cell carcinoma of the oral cavity (n=96) using immunohistochemistry and was correlated with clinicopathological features as well as outcome. Twenty-four (25%) cases showed no detectable PSMA staining, 48 (50%) demonstrated positive immunoreactivity for PSMA in less than 50% of microvessels and 24 (25%) cases showed strong endothelial PSMA expression in more than 50% of tumor-associated microvessels. High endothelial PSMA expression was associated with greatly reduced survival (18.2 vs 77.3 months; P=0.0001) and maintained prognostic significance after adjusting for grade and stage in multivariate analysis (hazard ratio=2.19, P=0.007). Furthermore, we observed a strong association between endothelial PSMA and cancer cell-specific COX2 expression. In conclusion, we provide the first evidence for the prognostic significance of endothelial PSMA expression in oral squamous cell carcinoma and, suggest a potential interaction between arachidonic acid metabolites and endothelial PSMA expression in the tumor neo-vasculature.
AB - Prostate-specific membrane antigen (PSMA) is a transmembrane protein expressed in prostate cancer as well as in the neo-vasculature of nonprostatic solid tumors. Here, we determined the expression pattern of PSMA in the vasculature of oral squamous cell carcinoma. Using a previously validated antibody, PSMA staining distribution and cyclooxygenase 2 (COX2) expression status was evaluated in a cohort of patients with squamous cell carcinoma of the oral cavity (n=96) using immunohistochemistry and was correlated with clinicopathological features as well as outcome. Twenty-four (25%) cases showed no detectable PSMA staining, 48 (50%) demonstrated positive immunoreactivity for PSMA in less than 50% of microvessels and 24 (25%) cases showed strong endothelial PSMA expression in more than 50% of tumor-associated microvessels. High endothelial PSMA expression was associated with greatly reduced survival (18.2 vs 77.3 months; P=0.0001) and maintained prognostic significance after adjusting for grade and stage in multivariate analysis (hazard ratio=2.19, P=0.007). Furthermore, we observed a strong association between endothelial PSMA and cancer cell-specific COX2 expression. In conclusion, we provide the first evidence for the prognostic significance of endothelial PSMA expression in oral squamous cell carcinoma and, suggest a potential interaction between arachidonic acid metabolites and endothelial PSMA expression in the tumor neo-vasculature.
KW - COX2
KW - FOLH1
KW - oral squamous cell carcinoma
KW - prognosis
KW - prostate-specific membrane antigen
KW - PSMA
KW - vasculature
UR - http://www.scopus.com/inward/record.url?scp=84864549393&partnerID=8YFLogxK
UR - http://www.scopus.com/inward/citedby.url?scp=84864549393&partnerID=8YFLogxK
U2 - 10.1038/modpathol.2012.66
DO - 10.1038/modpathol.2012.66
M3 - Article
C2 - 22460809
AN - SCOPUS:84864549393
VL - 25
SP - 1079
EP - 1085
JO - Modern Pathology
JF - Modern Pathology
SN - 0893-3952
IS - 8
ER -