@inproceedings{f7f9a9b0ca5c452490d2acaaa2bba645,
title = "High efficiency capture of circulating tumor cells from patient blood using geometrically-enhanced differential immunocapture",
abstract = "Here we report the capture of circulating prostate tumor cells (PCTCs) from whole peripheral blood samples of patients with castrate-resistant prostate cancer. Using a microfluidic device geometry that maximizes streamline distortion and target cell-wall collisions, we have been able to capture cells with higher efficiencies and purities that exceed previously reported values. Potential applications for this device include capture of PCTCs to study the molecular mechanisms of clinical drug resistance, profiling of individual patients' CTCs in order to generate personalized chemotherapeutics, as well as real-time monitoring of chemotherapeutic efficacy using a non-invasive blood-based assay.",
keywords = "Blood, CTC, Immunocapture, Prostate",
author = "Gleghorn, {Jason P.} and Pratt, {Erica D.} and Loftus, {Matthew S.} and Levy, {Benjamin E.} and Bander, {Neil H.} and Nanus, {David M.} and Giannakakou, {Paraskevi A.} and Kirby, {Brian J.}",
note = "Copyright: Copyright 2014 Elsevier B.V., All rights reserved.; 13th International Conference on Miniaturized Systems for Chemistry and Life Sciences, MicroTAS 2009 ; Conference date: 01-11-2009 Through 05-11-2009",
year = "2009",
language = "English (US)",
isbn = "9780979806421",
series = "Proceedings of Conference, MicroTAS 2009 - The 13th International Conference on Miniaturized Systems for Chemistry and Life Sciences",
publisher = "Chemical and Biological Microsystems Society",
pages = "657--659",
booktitle = "Proceedings of Conference, MicroTAS 2009 - The 13th International Conference on Miniaturized Systems for Chemistry and Life Sciences",
}