High doses of gonadotropins have no detrimental effect on in vitro fertilization outcome in normal responders

T. Simon, S. Oehninger, J. Toner, D. Jones, S. Muasher

Research output: Contribution to journalArticle

Abstract

Objective: To examine the effect of high doses of gonadotropins on IVF outcome in normal (intermediate) responders. Design: Retrospective analysis of patients undergoing IVF therapy from 1990 to 1994 at our institution. Setting: Academic tertiary center. Patients: A homogeneous group of women that consisted of intermediate responders examined in their initial attempt and who received differing amounts of gonadotropins were examined. Interventions: All patients were stimulated using a combination of a GnRH- agonist and FSH and hMG and were allocated into two groups, based on the amount of gonadotropin administered initially (four or six ampules). Main Outcome Measures: Implantation and pregnancy (clinical and ongoing) rates were compared. Results: There were no significant differences between patients receiving high doses versus those patients receiving lower doses of gonadotropins with regard to implantation and pregnancy rates. Conclusions: We conclude that high doses of gonadotropins have no detrimental effect on IVF outcome in normal (intermediate) responders.

Original languageEnglish (US)
Pages (from-to)1333-1336
Number of pages4
JournalFertility and Sterility
Volume63
Issue number6
StatePublished - 1995
Externally publishedYes

Fingerprint

Fertilization in Vitro
Gonadotropins
Pregnancy Rate
Gonadotropin-Releasing Hormone
Outcome Assessment (Health Care)
Pregnancy

Keywords

  • GnRH-a
  • Gonadotropins
  • IVF
  • pregnancy rate

ASJC Scopus subject areas

  • Obstetrics and Gynecology

Cite this

Simon, T., Oehninger, S., Toner, J., Jones, D., & Muasher, S. (1995). High doses of gonadotropins have no detrimental effect on in vitro fertilization outcome in normal responders. Fertility and Sterility, 63(6), 1333-1336.

High doses of gonadotropins have no detrimental effect on in vitro fertilization outcome in normal responders. / Simon, T.; Oehninger, S.; Toner, J.; Jones, D.; Muasher, S.

In: Fertility and Sterility, Vol. 63, No. 6, 1995, p. 1333-1336.

Research output: Contribution to journalArticle

Simon, T, Oehninger, S, Toner, J, Jones, D & Muasher, S 1995, 'High doses of gonadotropins have no detrimental effect on in vitro fertilization outcome in normal responders', Fertility and Sterility, vol. 63, no. 6, pp. 1333-1336.
Simon, T. ; Oehninger, S. ; Toner, J. ; Jones, D. ; Muasher, S. / High doses of gonadotropins have no detrimental effect on in vitro fertilization outcome in normal responders. In: Fertility and Sterility. 1995 ; Vol. 63, No. 6. pp. 1333-1336.
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