Abstract
Objective: To examine the effect of high doses of gonadotropins on IVF outcome in normal (intermediate) responders. Design: Retrospective analysis of patients undergoing IVF therapy from 1990 to 1994 at our institution. Setting: Academic tertiary center. Patients: A homogeneous group of women that consisted of intermediate responders examined in their initial attempt and who received differing amounts of gonadotropins were examined. Interventions: All patients were stimulated using a combination of a GnRH- agonist and FSH and hMG and were allocated into two groups, based on the amount of gonadotropin administered initially (four or six ampules). Main Outcome Measures: Implantation and pregnancy (clinical and ongoing) rates were compared. Results: There were no significant differences between patients receiving high doses versus those patients receiving lower doses of gonadotropins with regard to implantation and pregnancy rates. Conclusions: We conclude that high doses of gonadotropins have no detrimental effect on IVF outcome in normal (intermediate) responders.
Original language | English (US) |
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Pages (from-to) | 1333-1336 |
Number of pages | 4 |
Journal | Fertility and sterility |
Volume | 63 |
Issue number | 6 |
DOIs | |
State | Published - 1995 |
Externally published | Yes |
Keywords
- GnRH-a
- Gonadotropins
- IVF
- pregnancy rate
ASJC Scopus subject areas
- Reproductive Medicine
- Obstetrics and Gynecology