High doses of gonadotropins have no detrimental effect on in vitro fertilization outcome in normal responders

T. Simon, S. Oehninger, J. Toner, D. Jones, S. Muasher

Research output: Contribution to journalArticle

Abstract

Objective: To examine the effect of high doses of gonadotropins on IVF outcome in normal (intermediate) responders. Design: Retrospective analysis of patients undergoing IVF therapy from 1990 to 1994 at our institution. Setting: Academic tertiary center. Patients: A homogeneous group of women that consisted of intermediate responders examined in their initial attempt and who received differing amounts of gonadotropins were examined. Interventions: All patients were stimulated using a combination of a GnRH- agonist and FSH and hMG and were allocated into two groups, based on the amount of gonadotropin administered initially (four or six ampules). Main Outcome Measures: Implantation and pregnancy (clinical and ongoing) rates were compared. Results: There were no significant differences between patients receiving high doses versus those patients receiving lower doses of gonadotropins with regard to implantation and pregnancy rates. Conclusions: We conclude that high doses of gonadotropins have no detrimental effect on IVF outcome in normal (intermediate) responders.

Original languageEnglish (US)
Pages (from-to)1333-1336
Number of pages4
JournalFertility and sterility
Volume63
Issue number6
DOIs
StatePublished - Jan 1 1995

Keywords

  • GnRH-a
  • Gonadotropins
  • IVF
  • pregnancy rate

ASJC Scopus subject areas

  • Reproductive Medicine
  • Obstetrics and Gynecology

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