TY - JOUR
T1 - High-dose, post-transplantation cyclophosphamide to promote graft-host tolerance after allogeneic hematopoietic stem cell transplantation
AU - Luznik, Leo
AU - Fuchs, Ephraim J.
N1 - Funding Information:
The research described herein was supported by grant CA15396 from the National
PY - 2010/7
Y1 - 2010/7
N2 - Graft-versus-host disease, or GVHD, is a major complication of allogeneic hematopoietic stem cell transplantation (alloHSCT) for the treatment of hematologic malignancies. Here, we describe a novel method for preventing GVHD after alloHSCT using high-dose, post-transplantation cyclophosphamide (Cy). Post-transplantation Cy promotes tolerance in alloreactive host and donor T cells, leading to suppression of both graft rejection and GVHD after alloHSCT. High-dose, post-transplantation Cy facilitates partially HLA-mismatched HSCT without severe GVHD and is effective as sole prophylaxis of GVHD after HLA-matched alloHSCT. By reducing the morbidity and mortality of alloHSCT, post-transplantation Cy may expand the applications of this therapy to the treatment of autoimmune diseases and non-malignant hematologic disorders such as sickle cell disease.
AB - Graft-versus-host disease, or GVHD, is a major complication of allogeneic hematopoietic stem cell transplantation (alloHSCT) for the treatment of hematologic malignancies. Here, we describe a novel method for preventing GVHD after alloHSCT using high-dose, post-transplantation cyclophosphamide (Cy). Post-transplantation Cy promotes tolerance in alloreactive host and donor T cells, leading to suppression of both graft rejection and GVHD after alloHSCT. High-dose, post-transplantation Cy facilitates partially HLA-mismatched HSCT without severe GVHD and is effective as sole prophylaxis of GVHD after HLA-matched alloHSCT. By reducing the morbidity and mortality of alloHSCT, post-transplantation Cy may expand the applications of this therapy to the treatment of autoimmune diseases and non-malignant hematologic disorders such as sickle cell disease.
KW - Bone marrow transplantation
KW - Cyclophosphamide
KW - Graft-versus-host disease
KW - Graft-versus-leukemia effect
KW - Human leukocyte antigens
KW - T lymphocytes
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U2 - 10.1007/s12026-009-8139-0
DO - 10.1007/s12026-009-8139-0
M3 - Review article
C2 - 20066512
AN - SCOPUS:77953959027
SN - 0257-277X
VL - 47
SP - 65
EP - 77
JO - Immunologic Research
JF - Immunologic Research
IS - 1-3
ER -