High-dose diazepam facilitates core cooling during cold saline infusion in healthy volunteers

David Hostler, William E. Northington, Clifton W. Callaway

Research output: Contribution to journalArticle

Abstract

Studies have suggested that inducing mild hypothermia improves neurologic outcomes after traumatic brain injury, major stroke, cardiac arrest, or exertional heat illness. While infusion of cold normal saline is a simple and inexpensive method for reducing core temperature, human cold-defense mechanisms potentially make this route stressful or ineffective. We hypothesized that intravenous administration of diazepam during a rapid infusion of 30 mL·kg-1 of cold (4 °C) 0.9% saline to healthy subjects would be more comfortable and reduce core body temperature more than the administration of cold saline alone. Fifteen subjects received rapidly infused cold (4 °C) 0.9% saline. Subjects were randomly assigned to receive, intravenously, 20 mg diazepam (HIGH), 10 mg diazepam (LOW), or placebo (CON). Main outcomes were core temperature, skin temperature, and oxygen consumption. Data for the main outcomes were analyzed with generalized estimating equations to identify differences in group, time, or a group × time interaction. Core temperature decreased in all groups (CON, 1.0 ± 0.2 °C; LOW, 1.4 ± 0.2 °C; HIGH, 1.5 ± 0.2 °C), while skin temperature was unchanged. Mean (95% CI) oxygen consumption was 315.3 (253.8, 376.9) mL-kg-1-min-1 in the CON group, 317.9 (275.5, 360.3) in the LOW group, and 226.1 (216.4, 235.9) in the HIGH group. Significant time and group × time interaction was observed for core temperature and oxygen consumption (p <0.001). Administration of high-dose diazepam resulted in decreased oxygen consumption during cold saline infusion, suggesting that 20 mg of intravenous diazepam may reduce the shivering threshold without compromising respiratory or cardiovascular function.

Original languageEnglish (US)
Pages (from-to)582-586
Number of pages5
JournalApplied Physiology, Nutrition and Metabolism
Volume34
Issue number4
DOIs
StatePublished - Aug 2009
Externally publishedYes

Fingerprint

Diazepam
Healthy Volunteers
Oxygen Consumption
Skin Temperature
Temperature
Shivering
Heart Arrest
Hypothermia
Body Temperature
Intravenous Administration
Nervous System
Hot Temperature
Stroke
Placebos

Keywords

  • Diazepam
  • Oxygen consumption
  • Shivering
  • Therapeutic hypothermia

ASJC Scopus subject areas

  • Physiology
  • Endocrinology, Diabetes and Metabolism
  • Nutrition and Dietetics
  • Physiology (medical)

Cite this

High-dose diazepam facilitates core cooling during cold saline infusion in healthy volunteers. / Hostler, David; Northington, William E.; Callaway, Clifton W.

In: Applied Physiology, Nutrition and Metabolism, Vol. 34, No. 4, 08.2009, p. 582-586.

Research output: Contribution to journalArticle

Hostler, David ; Northington, William E. ; Callaway, Clifton W. / High-dose diazepam facilitates core cooling during cold saline infusion in healthy volunteers. In: Applied Physiology, Nutrition and Metabolism. 2009 ; Vol. 34, No. 4. pp. 582-586.
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