High-dose cyclophosphamide for autoimmunity and alloimmunity

Research output: Contribution to journalReview articlepeer-review

Abstract

High-dose cyclophosphamide (high-CY) is a potent immunosuppressive regimen that is increasingly used to mitigate both autoimmune and alloimmune conditions. Differential expression of aldehyde dehydrogenase between hematopoietic stem cells and lymphocytes accounts for the differential sensitivity of these cells to high-CY and explains why this regimen is immunosuppressive but not myeloablative. This article describes the clinical translation of high-CY for the treatment of autoimmune and alloimmune conditions.

Original languageEnglish (US)
Pages (from-to)179-184
Number of pages6
JournalImmunologic Research
Volume47
Issue number1-3
DOIs
StatePublished - Jul 2010

Keywords

  • Aplastic anemia
  • Autoimmunity
  • Bone marrow transplantation
  • Cyclophosphamide

ASJC Scopus subject areas

  • Immunology

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