TY - GEN
T1 - High dimensional latent Gaussian copula model for mixed data in imaging genetics
AU - Zhang, Aiying
AU - Fang, Jian
AU - Calhoun, Vince D.
AU - Wang, Yu Ping
N1 - Publisher Copyright:
© 2018 IEEE.
PY - 2018/5/23
Y1 - 2018/5/23
N2 - Recent advances in imaging genetics combine different types of data including medical images like functional MRI images and genetic data like single nucleotide polymorphisms (SNPs). Many studies have proved that several mental diseases such as autism, ADHD, schizophrenia are affected by gene mutations. Understanding the complex interactions among these heterogeneous datasets may give rise to a new perspective for diseases diagnosis and prevention. In statistics, various graphical models have been proposed for the study of association networks with continuous data, binary data, and count data as well as the mixture of them. However, limited efforts have been made for the multinomial case, which has a direct application for SNP data. Therefore, in this paper, we propose a latent Gaussian copula model for mixed data containing multinomial components, which fills a vacancy of graphical models in imaging genetics. The performance of the proposed methods is first numerically assessed through simulation studies. Then it is validated with fMRI and SNP data collected by the Mind Clinical Imaging Consortium (MCIC) for a schizophrenia study.
AB - Recent advances in imaging genetics combine different types of data including medical images like functional MRI images and genetic data like single nucleotide polymorphisms (SNPs). Many studies have proved that several mental diseases such as autism, ADHD, schizophrenia are affected by gene mutations. Understanding the complex interactions among these heterogeneous datasets may give rise to a new perspective for diseases diagnosis and prevention. In statistics, various graphical models have been proposed for the study of association networks with continuous data, binary data, and count data as well as the mixture of them. However, limited efforts have been made for the multinomial case, which has a direct application for SNP data. Therefore, in this paper, we propose a latent Gaussian copula model for mixed data containing multinomial components, which fills a vacancy of graphical models in imaging genetics. The performance of the proposed methods is first numerically assessed through simulation studies. Then it is validated with fMRI and SNP data collected by the Mind Clinical Imaging Consortium (MCIC) for a schizophrenia study.
KW - Gaussian copula model
KW - Graphical model
KW - Imaging genetics
KW - Mixed data
UR - http://www.scopus.com/inward/record.url?scp=85048133812&partnerID=8YFLogxK
UR - http://www.scopus.com/inward/citedby.url?scp=85048133812&partnerID=8YFLogxK
U2 - 10.1109/ISBI.2018.8363533
DO - 10.1109/ISBI.2018.8363533
M3 - Conference contribution
AN - SCOPUS:85048133812
T3 - Proceedings - International Symposium on Biomedical Imaging
SP - 105
EP - 109
BT - 2018 IEEE 15th International Symposium on Biomedical Imaging, ISBI 2018
PB - IEEE Computer Society
T2 - 15th IEEE International Symposium on Biomedical Imaging, ISBI 2018
Y2 - 4 April 2018 through 7 April 2018
ER -