Abstract
In this study the laminar localization of binding sites for the muscarinic radioligand [3H]3-quinuclidinylbenzilate was studied in somatosensory cortex of infant rat. Using light autoradiographic techniques, [3H]QNB was found to be concentrated in layer IV. Atropine-pretreated pups showed evenly dispersed, nonspecific binding in all layers. We conclude that cholinergic muscarinic receptors are concentrated in layer IV of infant rat somatosensory cortex. It is also in this lamina that an acetylcholinesterase-rich pathway terminates.
Original language | English (US) |
---|---|
Pages (from-to) | 373-376 |
Number of pages | 4 |
Journal | Developmental Brain Research |
Volume | 8 |
Issue number | 2-3 |
DOIs | |
State | Published - Jun 1983 |
Externally published | Yes |
Keywords
- acetylcholinesterase
- brain development
- cholinergic receptors
- somatosensory cortex
ASJC Scopus subject areas
- Developmental Neuroscience
- Developmental Biology