Abstract
In this study the laminar localization of binding sites for the muscarinic radioligand [3H]3-quinuclidinylbenzilate was studied in somatosensory cortex of infant rat. Using light autoradiographic techniques, [3H]QNB was found to be concentrated in layer IV. Atropine-pretreated pups showed evenly dispersed, nonspecific binding in all layers. We conclude that cholinergic muscarinic receptors are concentrated in layer IV of infant rat somatosensory cortex. It is also in this lamina that an acetylcholinesterase-rich pathway terminates.
| Original language | English (US) |
|---|---|
| Pages (from-to) | 373-376 |
| Number of pages | 4 |
| Journal | Brain Research |
| Volume | 284 |
| Issue number | 2-3 |
| State | Published - Jun 1983 |
| Externally published | Yes |
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ASJC Scopus subject areas
- Neuroscience(all)
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High density of cholinergic muscarinic receptors accompanies high intensity acetylcholinesterase-staining in layer IV of infant rat somatosensory cortex. / Kristt, D. A.; Kasper, Edward K.
In: Brain Research, Vol. 284, No. 2-3, 06.1983, p. 373-376.Research output: Contribution to journal › Article
}
TY - JOUR
T1 - High density of cholinergic muscarinic receptors accompanies high intensity acetylcholinesterase-staining in layer IV of infant rat somatosensory cortex.
AU - Kristt, D. A.
AU - Kasper, Edward K
PY - 1983/6
Y1 - 1983/6
N2 - In this study the laminar localization of binding sites for the muscarinic radioligand [3H]3-quinuclidinylbenzilate was studied in somatosensory cortex of infant rat. Using light autoradiographic techniques, [3H]QNB was found to be concentrated in layer IV. Atropine-pretreated pups showed evenly dispersed, nonspecific binding in all layers. We conclude that cholinergic muscarinic receptors are concentrated in layer IV of infant rat somatosensory cortex. It is also in this lamina that an acetylcholinesterase-rich pathway terminates.
AB - In this study the laminar localization of binding sites for the muscarinic radioligand [3H]3-quinuclidinylbenzilate was studied in somatosensory cortex of infant rat. Using light autoradiographic techniques, [3H]QNB was found to be concentrated in layer IV. Atropine-pretreated pups showed evenly dispersed, nonspecific binding in all layers. We conclude that cholinergic muscarinic receptors are concentrated in layer IV of infant rat somatosensory cortex. It is also in this lamina that an acetylcholinesterase-rich pathway terminates.
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UR - http://www.scopus.com/inward/citedby.url?scp=0020775429&partnerID=8YFLogxK
M3 - Article
C2 - 6871730
AN - SCOPUS:0020775429
VL - 284
SP - 373
EP - 376
JO - Brain Research
JF - Brain Research
SN - 0006-8993
IS - 2-3
ER -