High density of cholinergic muscarinic receptors accompanies high intensity acetylcholinesterase-staining in layer IV of infant rat somatosensory cortex

Donald A. Kristt; Edward K. Kasper

doi:10.1016/0165-3806(83)90018-4

High density of cholinergic muscarinic receptors accompanies high intensity acetylcholinesterase-staining in layer IV of infant rat somatosensory cortex

Donald A. Kristt, Edward K. Kasper

Research output: Contribution to journal › Article › peer-review

19 Scopus citations

Abstract

In this study the laminar localization of binding sites for the muscarinic radioligand [³H]3-quinuclidinylbenzilate was studied in somatosensory cortex of infant rat. Using light autoradiographic techniques, [³H]QNB was found to be concentrated in layer IV. Atropine-pretreated pups showed evenly dispersed, nonspecific binding in all layers. We conclude that cholinergic muscarinic receptors are concentrated in layer IV of infant rat somatosensory cortex. It is also in this lamina that an acetylcholinesterase-rich pathway terminates.

Original language	English (US)
Pages (from-to)	373-376
Number of pages	4
Journal	Developmental Brain Research
Volume	8
Issue number	2-3
DOIs	https://doi.org/10.1016/0165-3806(83)90018-4
State	Published - Jun 1983
Externally published	Yes

Keywords

acetylcholinesterase
brain development
cholinergic receptors
somatosensory cortex

ASJC Scopus subject areas

Developmental Neuroscience
Developmental Biology

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10.1016/0165-3806(83)90018-4

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title = "High density of cholinergic muscarinic receptors accompanies high intensity acetylcholinesterase-staining in layer IV of infant rat somatosensory cortex",

abstract = "In this study the laminar localization of binding sites for the muscarinic radioligand [3H]3-quinuclidinylbenzilate was studied in somatosensory cortex of infant rat. Using light autoradiographic techniques, [3H]QNB was found to be concentrated in layer IV. Atropine-pretreated pups showed evenly dispersed, nonspecific binding in all layers. We conclude that cholinergic muscarinic receptors are concentrated in layer IV of infant rat somatosensory cortex. It is also in this lamina that an acetylcholinesterase-rich pathway terminates.",

keywords = "acetylcholinesterase, brain development, cholinergic receptors, somatosensory cortex",

author = "Kristt, {Donald A.} and Kasper, {Edward K.}",

note = "Funding Information: Supported by NSF Grant BNS 81-40895. Our thanks to G. Hoffman and M. Kuhar for critically commentingo n the manuscriptt, o C. Ross and R. J. Stone for typing it, and B. Gray and D. Trythall for technicaal ssistance.",

year = "1983",

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doi = "10.1016/0165-3806(83)90018-4",

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journal = "Developmental Brain Research",

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T1 - High density of cholinergic muscarinic receptors accompanies high intensity acetylcholinesterase-staining in layer IV of infant rat somatosensory cortex

AU - Kristt, Donald A.

AU - Kasper, Edward K.

N1 - Funding Information: Supported by NSF Grant BNS 81-40895. Our thanks to G. Hoffman and M. Kuhar for critically commentingo n the manuscriptt, o C. Ross and R. J. Stone for typing it, and B. Gray and D. Trythall for technicaal ssistance.

PY - 1983/6

Y1 - 1983/6

N2 - In this study the laminar localization of binding sites for the muscarinic radioligand [3H]3-quinuclidinylbenzilate was studied in somatosensory cortex of infant rat. Using light autoradiographic techniques, [3H]QNB was found to be concentrated in layer IV. Atropine-pretreated pups showed evenly dispersed, nonspecific binding in all layers. We conclude that cholinergic muscarinic receptors are concentrated in layer IV of infant rat somatosensory cortex. It is also in this lamina that an acetylcholinesterase-rich pathway terminates.

AB - In this study the laminar localization of binding sites for the muscarinic radioligand [3H]3-quinuclidinylbenzilate was studied in somatosensory cortex of infant rat. Using light autoradiographic techniques, [3H]QNB was found to be concentrated in layer IV. Atropine-pretreated pups showed evenly dispersed, nonspecific binding in all layers. We conclude that cholinergic muscarinic receptors are concentrated in layer IV of infant rat somatosensory cortex. It is also in this lamina that an acetylcholinesterase-rich pathway terminates.

KW - acetylcholinesterase

KW - brain development

KW - cholinergic receptors

KW - somatosensory cortex

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VL - 8

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JO - Developmental Brain Research

JF - Developmental Brain Research

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High density of cholinergic muscarinic receptors accompanies high intensity acetylcholinesterase-staining in layer IV of infant rat somatosensory cortex

Abstract

Keywords

ASJC Scopus subject areas

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