High density of cholinergic muscarinic receptors accompanies high intensity acetylcholinesterase-staining in layer IV of infant rat somatosensory cortex

Donald A. Kristt, Edward K. Kasper

Research output: Contribution to journalArticlepeer-review

Abstract

In this study the laminar localization of binding sites for the muscarinic radioligand [3H]3-quinuclidinylbenzilate was studied in somatosensory cortex of infant rat. Using light autoradiographic techniques, [3H]QNB was found to be concentrated in layer IV. Atropine-pretreated pups showed evenly dispersed, nonspecific binding in all layers. We conclude that cholinergic muscarinic receptors are concentrated in layer IV of infant rat somatosensory cortex. It is also in this lamina that an acetylcholinesterase-rich pathway terminates.

Original languageEnglish (US)
Pages (from-to)373-376
Number of pages4
JournalDevelopmental Brain Research
Volume8
Issue number2-3
DOIs
StatePublished - Jun 1983
Externally publishedYes

Keywords

  • acetylcholinesterase
  • brain development
  • cholinergic receptors
  • somatosensory cortex

ASJC Scopus subject areas

  • Developmental Neuroscience
  • Developmental Biology

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