High density of cholinergic muscarinic receptors accompanies high intensity acetylcholinesterase-staining in layer IV of infant rat somatosensory cortex.

D. A. Kristt, Edward K Kasper

Research output: Contribution to journalArticle

Abstract

In this study the laminar localization of binding sites for the muscarinic radioligand [3H]3-quinuclidinylbenzilate was studied in somatosensory cortex of infant rat. Using light autoradiographic techniques, [3H]QNB was found to be concentrated in layer IV. Atropine-pretreated pups showed evenly dispersed, nonspecific binding in all layers. We conclude that cholinergic muscarinic receptors are concentrated in layer IV of infant rat somatosensory cortex. It is also in this lamina that an acetylcholinesterase-rich pathway terminates.

Original languageEnglish (US)
Pages (from-to)373-376
Number of pages4
JournalBrain Research
Volume284
Issue number2-3
StatePublished - Jun 1983
Externally publishedYes

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Somatosensory Cortex
Cholinergic Receptors
Muscarinic Receptors
Acetylcholinesterase
Staining and Labeling
Atropine
Cholinergic Agents
Binding Sites
Light

ASJC Scopus subject areas

  • Neuroscience(all)

Cite this

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