High concentration of somatostatin immunoreactivity in chicken pancreas

G. C. Weir; P. C. Goltsos; E. P. Steinberg; Y. C. Pate

doi:10.1007/BF00428977

High concentration of somatostatin immunoreactivity in chicken pancreas

G. C. Weir, P. C. Goltsos, E. P. Steinberg, Y. C. Pate

Research output: Contribution to journal › Article › peer-review

49 Scopus citations

Abstract

Extracts of discrete lobes of chicken pancreas were assayed for somatostatin (SRIF), insulin, and glucagon immunoreactivity. The distribution of hormone concentration was correlated appropriately with the known distribution of A, B, and D-cells. Concentrations of all three hormones were highest in the splenic lobe. The glucagon content of the ventral and dorsal lobes was low. Evidence is presented that the SRIF-like material in the pancreatic extracts is very similar to synthetic cyclic SRIF; parallel immunoassay displacement curves and similar chromatographic elution profiles were obtained. The SRIF concentration in chicken pancreas is 21 times higher than that found in the rat. Chicken pancreas may provide a useful model for studies of somatostatin physiology.

Original language	English (US)
Pages (from-to)	129-132
Number of pages	4
Journal	Diabetologia
Volume	12
Issue number	2
DOIs	https://doi.org/10.1007/BF00428977
State	Published - May 1976
Externally published	Yes

Keywords

Chicken pancreas
glucagon
insulin
somatostatin

ASJC Scopus subject areas

Internal Medicine
Endocrinology, Diabetes and Metabolism

Access to Document

10.1007/BF00428977

Cite this

@article{ca190f43bcd14979afef73374f812bd6,

title = "High concentration of somatostatin immunoreactivity in chicken pancreas",

abstract = "Extracts of discrete lobes of chicken pancreas were assayed for somatostatin (SRIF), insulin, and glucagon immunoreactivity. The distribution of hormone concentration was correlated appropriately with the known distribution of A, B, and D-cells. Concentrations of all three hormones were highest in the splenic lobe. The glucagon content of the ventral and dorsal lobes was low. Evidence is presented that the SRIF-like material in the pancreatic extracts is very similar to synthetic cyclic SRIF; parallel immunoassay displacement curves and similar chromatographic elution profiles were obtained. The SRIF concentration in chicken pancreas is 21 times higher than that found in the rat. Chicken pancreas may provide a useful model for studies of somatostatin physiology.",

keywords = "Chicken pancreas, glucagon, insulin, somatostatin",

author = "Weir, {G. C.} and Goltsos, {P. C.} and Steinberg, {E. P.} and Pate, {Y. C.}",

year = "1976",

month = may,

doi = "10.1007/BF00428977",

language = "English (US)",

volume = "12",

pages = "129--132",

journal = "Diabetologia",

issn = "0012-186X",

publisher = "Springer Verlag",

number = "2",

}

TY - JOUR

T1 - High concentration of somatostatin immunoreactivity in chicken pancreas

AU - Weir, G. C.

AU - Goltsos, P. C.

AU - Steinberg, E. P.

AU - Pate, Y. C.

PY - 1976/5

Y1 - 1976/5

N2 - Extracts of discrete lobes of chicken pancreas were assayed for somatostatin (SRIF), insulin, and glucagon immunoreactivity. The distribution of hormone concentration was correlated appropriately with the known distribution of A, B, and D-cells. Concentrations of all three hormones were highest in the splenic lobe. The glucagon content of the ventral and dorsal lobes was low. Evidence is presented that the SRIF-like material in the pancreatic extracts is very similar to synthetic cyclic SRIF; parallel immunoassay displacement curves and similar chromatographic elution profiles were obtained. The SRIF concentration in chicken pancreas is 21 times higher than that found in the rat. Chicken pancreas may provide a useful model for studies of somatostatin physiology.

AB - Extracts of discrete lobes of chicken pancreas were assayed for somatostatin (SRIF), insulin, and glucagon immunoreactivity. The distribution of hormone concentration was correlated appropriately with the known distribution of A, B, and D-cells. Concentrations of all three hormones were highest in the splenic lobe. The glucagon content of the ventral and dorsal lobes was low. Evidence is presented that the SRIF-like material in the pancreatic extracts is very similar to synthetic cyclic SRIF; parallel immunoassay displacement curves and similar chromatographic elution profiles were obtained. The SRIF concentration in chicken pancreas is 21 times higher than that found in the rat. Chicken pancreas may provide a useful model for studies of somatostatin physiology.

KW - Chicken pancreas

KW - glucagon

KW - insulin

KW - somatostatin

UR - http://www.scopus.com/inward/record.url?scp=0017195897&partnerID=8YFLogxK

UR - http://www.scopus.com/inward/citedby.url?scp=0017195897&partnerID=8YFLogxK

U2 - 10.1007/BF00428977

DO - 10.1007/BF00428977

M3 - Article

C2 - 773728

AN - SCOPUS:0017195897

SN - 0012-186X

VL - 12

SP - 129

EP - 132

JO - Diabetologia

JF - Diabetologia

IS - 2

ER -

High concentration of somatostatin immunoreactivity in chicken pancreas

Abstract

Keywords

ASJC Scopus subject areas

Access to Document

Other files and links

Fingerprint

Cite this