Índice de masa corporal elevado como factor de riesgo de hospitalización por gripe: Estudio de casos y controles

Translated title of the contribution: High Body Mass Index as a Risk Factor for Hospitalization Due to Influenza: A Case-Control Study

Vicente Martín, Jesús Castilla, Pere Godoy, Miguel Delgado-Rodríguez, Nuria Soldevila, Tania Fernández-Villa, Antonio J. Molina, Jenaro Astray, Ady Castro, Fernando González-Candelas, José María Mayoral, José María Quintana, Ángela Domínguez, E. Azor, J. Carrillo, R. Moyano, J. A. Navarro, M. Vázquez, F. Zafra, M. A. BuenoM. Delgado, M. L. Gómez, M. Mariscal, B. Martínez, J. P. Quesada, M. Sillero, M. Carnero, J. Fernández-Crehuet, J. del Diego Salas, V. Fuentes, V. Gallardo, E. Pérez, R. López, J. R. Maldonado, A. Morillo, I. Pedrosa Corral, M. F. Bautista, J. M. Navarro, M. Pérez, S. Oña, M. J. Pérez, M. C. Ubago, M. Zarzuela, J. M. Mayoral, F. González, J. Blanquer, M. Morales, T. Fernandez, V. Martín, A. Molina, P. Sanz, D. Carriedo, F. Díez, I. Fernández-Natal, S. Fernández, Castrodeza J.J. Castrodeza, A. Pérez, S. Tama-mes, R. Ortiz de Lejarazu, J. Ortiz de Saracho, A. Pueyo, J. L. Viejo, P. Redondo, A. Domínguez, A. Agustí, A. Torres, A. Trilla, A. Vilella, F. Barbé, L. Blanch, G. Navarro, X. Bonfill, J. López-Contreras, V. Pomar, M. T. Puig, E. Borràs, N. Martínez, A. Torner, P. Godoy, C. Bravo, F. Moraga, F. Calafell, J. Caylà, C. Tortajada, J. Garcia, I. Ruiz, García J.J. García, M. Baricot, N. Soldevila, O. Garín, J. Alonso, J. Gea, J. P. Horcajada, T. Pumarola, N. Hayes, A. Rosell, J. Dorca, Saez Marc Saez, C. álva-rez, M. Enríquez, A. Hernández Voth, F. Pozo, F. Baquero, R. Cantón, J. C. Galán, A. Robustillo, M. Valdeón, J. Astray, E. Córdoba, F. Domínguez, M. García Barquero, J. García, R. Génova, E. Gil, S. Jiménez, M. A. Lopaz, J. López, F. Martín, M. L. Martínez, M. Ordobás, E. Rodriguez, S. Sánchez, C. Valdés, Paño J.R. Paño, M. Romero, J. Castilla, A. Martínez, L. Martínez, M. Ruiz, P. Fanlo, F. Gil, V. Martínez-Artola, Ursua M.E. Ursua, M. Sota, M. T. Virto, J. Gamboa, F. Pérez-Afonso, U. Aguirre, A. Caspelastegui, P. P. España, S. García, J. M. Quintana, Antoñana J.M. Antoñana, I. Astigarraga, J. I. Pijoan, I. Pocheville, M. Santiago, J. I. Villate, J. Arístegui, A. Esco-bar, M. I. Garrote, A. Bilbao, C. Garaizar, G. Cilla, J. Korta, E. Pérez-Trallero, C. Sarasqueta, F. Aizpuru, C. Lobo, J. L. Salado, J. Alustiza, F. J. Troya

Research output: Contribution to journalArticle

Abstract

Introduction: Obesity has emerged as a significant independent predictor of severity in pandemic influenza A (H1N1)pdm09. The aim of this study was to investigate the association between body mass index (BMI) and the risk of hospitalization due to influenza. Methods: Hospitalized patients (n = 755) with laboratory-confirmed influenza were individually matched by age, admission/visit date, and province with an outpatient (n = 783) with laboratory-confirmed influenza and an outpatient control (n = 950). We compared the BMI using conditional logistic regression adjusted for potential confounding factors (aOR). The population attributable fraction (PAF) was calculated. Results: A higher BMI was associated with an increased risk of hospitalization compared to both outpatient cases (aOR = 1.11; 95% CI: 1.07-1.16) and outpatient controls (aOR = 1.04; 95% CI: 1.01-1.07). Compared with normal weight, obesity type I, obesity type II and obesity type III was associated with a greater likelihood of hospitalization compared with outpatient cases (aOR = 1.85, 95% CI: 1.05-3.26; aOR = 5.24, 95% CI: 1.94-14.15 and aOR = 44.38, 95% CI: 4.47-440.5). Compared with normal weight, obesity type II and obesity type III was associated with a greater likelihood of hospitalization compared with outpatient controls (aOR = 4.37, 95% CI: 1.79-10.69 and aOR = 4.95, 95% CI: 1.45-16.87). In persons without influenza vaccination, all categories of BMI ≥ 30 kg/m2 were associated with a greater likelihood of hospitalization compared with normal weight in both outpatient cases and outpatient controls. The PAF of hospitalization by influenza due to BMI ranged from 21.9% to 8.5%; in the case of unvaccinated against influenza between 20.5% to 16.9%. Conclusion: A high BMI is associated with an increased risk of hospitalization due to influenza. High percentage of hospital admissions are attributable to their BMI, especially in non vaccinated.

Original languageSpanish
Pages (from-to)299-307
Number of pages9
JournalArchivos de Bronconeumologia
Volume52
Issue number6
DOIs
StatePublished - Jun 1 2016
Externally publishedYes

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Keywords

  • Body mass index
  • Case control study
  • Hospitalization risk
  • Influenza
  • Obesity
  • Population attributable fraction

ASJC Scopus subject areas

  • Pulmonary and Respiratory Medicine

Cite this

Martín, V., Castilla, J., Godoy, P., Delgado-Rodríguez, M., Soldevila, N., Fernández-Villa, T., Molina, A. J., Astray, J., Castro, A., González-Candelas, F., Mayoral, J. M., Quintana, J. M., Domínguez, Á., Azor, E., Carrillo, J., Moyano, R., Navarro, J. A., Vázquez, M., Zafra, F., ... Troya, F. J. (2016). Índice de masa corporal elevado como factor de riesgo de hospitalización por gripe: Estudio de casos y controles. Archivos de Bronconeumologia, 52(6), 299-307. https://doi.org/10.1016/j.arbres.2015.11.006