Índice de masa corporal elevado como factor de riesgo de hospitalización por gripe

Estudio de casos y controles

Translated title of the contribution: High Body Mass Index as a Risk Factor for Hospitalization Due to Influenza: A Case-Control Study

Vicente Martín, Jesús Castilla, Pere Godoy, Miguel Delgado-Rodríguez, Nuria Soldevila, Tania Fernández-Villa, Antonio J. Molina, Jenaro Astray, Ady Castro, Fernando González-Candelas, José María Mayoral, José María Quintana, Ángela Domínguez, E. Azor, J. Carrillo, R. Moyano, J. A. Navarro, M. Vázquez, F. Zafra, M. A. Bueno & 142 others M. Delgado, M. L. Gómez, M. Mariscal, B. Martínez, J. P. Quesada, M. Sillero, M. Carnero, J. Fernández-Crehuet, J. del Diego Salas, V. Fuentes, V. Gallardo, E. Pérez, R. López, J. R. Maldonado, A. Morillo, I. Pedrosa Corral, M. F. Bautista, J. M. Navarro, M. Pérez, S. Oña, M. J. Pérez, M. C. Ubago, M. Zarzuela, J. M. Mayoral, F. González, J. Blanquer, M. Morales, T. Fernandez, V. Martín, A. Molina, P. Sanz, D. Carriedo, F. Díez, I. Fernández-Natal, S. Fernández, Castrodeza J.J. Castrodeza, A. Pérez, S. Tama-mes, R. Ortiz de Lejarazu, J. Ortiz de Saracho, A. Pueyo, J. L. Viejo, P. Redondo, A. Domínguez, A. Agustí, A. Torres, A. Trilla, A. Vilella, F. Barbé, L. Blanch, G. Navarro, X. Bonfill, J. López-Contreras, V. Pomar, M. T. Puig, E. Borràs, N. Martínez, A. Torner, P. Godoy, C. Bravo, F. Moraga, F. Calafell, J. Caylà, C. Tortajada, J. Garcia, I. Ruiz, García J.J. García, M. Baricot, N. Soldevila, O. Garín, J. Alonso, J. Gea, J. P. Horcajada, T. Pumarola, N. Hayes, A. Rosell, J. Dorca, Saez Marc Saez, C. álva-rez, M. Enríquez, A. Hernández Voth, F. Pozo, F. Baquero, R. Cantón, J. C. Galán, A. Robustillo, M. Valdeón, J. Astray, E. Córdoba, F. Domínguez, M. García Barquero, J. García, R. Génova, E. Gil, S. Jiménez, M. A. Lopaz, J. López, F. Martín, M. L. Martínez, M. Ordobás, E. Rodriguez, S. Sánchez, C. Valdés, Paño J.R. Paño, M. Romero, J. Castilla, A. Martínez, L. Martínez, M. Ruiz, P. Fanlo, F. Gil, V. Martínez-Artola, Ursua M.E. Ursua, M. Sota, M. T. Virto, J. Gamboa, F. Pérez-Afonso, U. Aguirre, A. Caspelastegui, P. P. España, S. García, J. M. Quintana, Antoñana J.M. Antoñana, I. Astigarraga, J. I. Pijoan, I. Pocheville, M. Santiago, J. I. Villate, J. Arístegui, A. Esco-bar, M. I. Garrote, A. Bilbao, C. Garaizar, G. Cilla, J. Korta, E. Pérez-Trallero, C. Sarasqueta, F. Aizpuru, C. Lobo, J. L. Salado, J. Alustiza, F. J. Troya

Research output: Contribution to journalArticle

Abstract

Introduction: Obesity has emerged as a significant independent predictor of severity in pandemic influenza A (H1N1)pdm09. The aim of this study was to investigate the association between body mass index (BMI) and the risk of hospitalization due to influenza. Methods: Hospitalized patients (n = 755) with laboratory-confirmed influenza were individually matched by age, admission/visit date, and province with an outpatient (n = 783) with laboratory-confirmed influenza and an outpatient control (n = 950). We compared the BMI using conditional logistic regression adjusted for potential confounding factors (aOR). The population attributable fraction (PAF) was calculated. Results: A higher BMI was associated with an increased risk of hospitalization compared to both outpatient cases (aOR = 1.11; 95% CI: 1.07-1.16) and outpatient controls (aOR = 1.04; 95% CI: 1.01-1.07). Compared with normal weight, obesity type I, obesity type II and obesity type III was associated with a greater likelihood of hospitalization compared with outpatient cases (aOR = 1.85, 95% CI: 1.05-3.26; aOR = 5.24, 95% CI: 1.94-14.15 and aOR = 44.38, 95% CI: 4.47-440.5). Compared with normal weight, obesity type II and obesity type III was associated with a greater likelihood of hospitalization compared with outpatient controls (aOR = 4.37, 95% CI: 1.79-10.69 and aOR = 4.95, 95% CI: 1.45-16.87). In persons without influenza vaccination, all categories of BMI ≥ 30 kg/m2 were associated with a greater likelihood of hospitalization compared with normal weight in both outpatient cases and outpatient controls. The PAF of hospitalization by influenza due to BMI ranged from 21.9% to 8.5%; in the case of unvaccinated against influenza between 20.5% to 16.9%. Conclusion: A high BMI is associated with an increased risk of hospitalization due to influenza. High percentage of hospital admissions are attributable to their BMI, especially in non vaccinated.

Original languageSpanish
Pages (from-to)299-307
Number of pages9
JournalArchivos de Bronconeumologia
Volume52
Issue number6
DOIs
StatePublished - Jun 1 2016
Externally publishedYes

Fingerprint

Human Influenza
Case-Control Studies
Hospitalization
Body Mass Index
Outpatients
Obesity
Weights and Measures
Pandemics
Population
Vaccination
Logistic Models

Keywords

  • Body mass index
  • Case control study
  • Hospitalization risk
  • Influenza
  • Obesity
  • Population attributable fraction

ASJC Scopus subject areas

  • Pulmonary and Respiratory Medicine

Cite this

Martín, V., Castilla, J., Godoy, P., Delgado-Rodríguez, M., Soldevila, N., Fernández-Villa, T., ... Troya, F. J. (2016). Índice de masa corporal elevado como factor de riesgo de hospitalización por gripe: Estudio de casos y controles. Archivos de Bronconeumologia, 52(6), 299-307. https://doi.org/10.1016/j.arbres.2015.11.006

Índice de masa corporal elevado como factor de riesgo de hospitalización por gripe : Estudio de casos y controles. / Martín, Vicente; Castilla, Jesús; Godoy, Pere; Delgado-Rodríguez, Miguel; Soldevila, Nuria; Fernández-Villa, Tania; Molina, Antonio J.; Astray, Jenaro; Castro, Ady; González-Candelas, Fernando; Mayoral, José María; Quintana, José María; Domínguez, Ángela; Azor, E.; Carrillo, J.; Moyano, R.; Navarro, J. A.; Vázquez, M.; Zafra, F.; Bueno, M. A.; Delgado, M.; Gómez, M. L.; Mariscal, M.; Martínez, B.; Quesada, J. P.; Sillero, M.; Carnero, M.; Fernández-Crehuet, J.; del Diego Salas, J.; Fuentes, V.; Gallardo, V.; Pérez, E.; López, R.; Maldonado, J. R.; Morillo, A.; Pedrosa Corral, I.; Bautista, M. F.; Navarro, J. M.; Pérez, M.; Oña, S.; Pérez, M. J.; Ubago, M. C.; Zarzuela, M.; Mayoral, J. M.; González, F.; Blanquer, J.; Morales, M.; Fernandez, T.; Martín, V.; Molina, A.; Sanz, P.; Carriedo, D.; Díez, F.; Fernández-Natal, I.; Fernández, S.; J.J. Castrodeza, Castrodeza; Pérez, A.; Tama-mes, S.; Ortiz de Lejarazu, R.; Ortiz de Saracho, J.; Pueyo, A.; Viejo, J. L.; Redondo, P.; Domínguez, A.; Agustí, A.; Torres, A.; Trilla, A.; Vilella, A.; Barbé, F.; Blanch, L.; Navarro, G.; Bonfill, X.; López-Contreras, J.; Pomar, V.; Puig, M. T.; Borràs, E.; Martínez, N.; Torner, A.; Godoy, P.; Bravo, C.; Moraga, F.; Calafell, F.; Caylà, J.; Tortajada, C.; Garcia, J.; Ruiz, I.; J.J. García, García; Baricot, M.; Soldevila, N.; Garín, O.; Alonso, J.; Gea, J.; Horcajada, J. P.; Pumarola, T.; Hayes, N.; Rosell, A.; Dorca, J.; Marc Saez, Saez; álva-rez, C.; Enríquez, M.; Hernández Voth, A.; Pozo, F.; Baquero, F.; Cantón, R.; Galán, J. C.; Robustillo, A.; Valdeón, M.; Astray, J.; Córdoba, E.; Domínguez, F.; García Barquero, M.; García, J.; Génova, R.; Gil, E.; Jiménez, S.; Lopaz, M. A.; López, J.; Martín, F.; Martínez, M. L.; Ordobás, M.; Rodriguez, E.; Sánchez, S.; Valdés, C.; J.R. Paño, Paño; Romero, M.; Castilla, J.; Martínez, A.; Martínez, L.; Ruiz, M.; Fanlo, P.; Gil, F.; Martínez-Artola, V.; M.E. Ursua, Ursua; Sota, M.; Virto, M. T.; Gamboa, J.; Pérez-Afonso, F.; Aguirre, U.; Caspelastegui, A.; España, P. P.; García, S.; Quintana, J. M.; J.M. Antoñana, Antoñana; Astigarraga, I.; Pijoan, J. I.; Pocheville, I.; Santiago, M.; Villate, J. I.; Arístegui, J.; Esco-bar, A.; Garrote, M. I.; Bilbao, A.; Garaizar, C.; Cilla, G.; Korta, J.; Pérez-Trallero, E.; Sarasqueta, C.; Aizpuru, F.; Lobo, C.; Salado, J. L.; Alustiza, J.; Troya, F. J.

In: Archivos de Bronconeumologia, Vol. 52, No. 6, 01.06.2016, p. 299-307.

Research output: Contribution to journalArticle

Martín, V, Castilla, J, Godoy, P, Delgado-Rodríguez, M, Soldevila, N, Fernández-Villa, T, Molina, AJ, Astray, J, Castro, A, González-Candelas, F, Mayoral, JM, Quintana, JM, Domínguez, Á, Azor, E, Carrillo, J, Moyano, R, Navarro, JA, Vázquez, M, Zafra, F, Bueno, MA, Delgado, M, Gómez, ML, Mariscal, M, Martínez, B, Quesada, JP, Sillero, M, Carnero, M, Fernández-Crehuet, J, del Diego Salas, J, Fuentes, V, Gallardo, V, Pérez, E, López, R, Maldonado, JR, Morillo, A, Pedrosa Corral, I, Bautista, MF, Navarro, JM, Pérez, M, Oña, S, Pérez, MJ, Ubago, MC, Zarzuela, M, Mayoral, JM, González, F, Blanquer, J, Morales, M, Fernandez, T, Martín, V, Molina, A, Sanz, P, Carriedo, D, Díez, F, Fernández-Natal, I, Fernández, S, J.J. Castrodeza, C, Pérez, A, Tama-mes, S, Ortiz de Lejarazu, R, Ortiz de Saracho, J, Pueyo, A, Viejo, JL, Redondo, P, Domínguez, A, Agustí, A, Torres, A, Trilla, A, Vilella, A, Barbé, F, Blanch, L, Navarro, G, Bonfill, X, López-Contreras, J, Pomar, V, Puig, MT, Borràs, E, Martínez, N, Torner, A, Godoy, P, Bravo, C, Moraga, F, Calafell, F, Caylà, J, Tortajada, C, Garcia, J, Ruiz, I, J.J. García, G, Baricot, M, Soldevila, N, Garín, O, Alonso, J, Gea, J, Horcajada, JP, Pumarola, T, Hayes, N, Rosell, A, Dorca, J, Marc Saez, S, álva-rez, C, Enríquez, M, Hernández Voth, A, Pozo, F, Baquero, F, Cantón, R, Galán, JC, Robustillo, A, Valdeón, M, Astray, J, Córdoba, E, Domínguez, F, García Barquero, M, García, J, Génova, R, Gil, E, Jiménez, S, Lopaz, MA, López, J, Martín, F, Martínez, ML, Ordobás, M, Rodriguez, E, Sánchez, S, Valdés, C, J.R. Paño, P, Romero, M, Castilla, J, Martínez, A, Martínez, L, Ruiz, M, Fanlo, P, Gil, F, Martínez-Artola, V, M.E. Ursua, U, Sota, M, Virto, MT, Gamboa, J, Pérez-Afonso, F, Aguirre, U, Caspelastegui, A, España, PP, García, S, Quintana, JM, J.M. Antoñana, A, Astigarraga, I, Pijoan, JI, Pocheville, I, Santiago, M, Villate, JI, Arístegui, J, Esco-bar, A, Garrote, MI, Bilbao, A, Garaizar, C, Cilla, G, Korta, J, Pérez-Trallero, E, Sarasqueta, C, Aizpuru, F, Lobo, C, Salado, JL, Alustiza, J & Troya, FJ 2016, 'Índice de masa corporal elevado como factor de riesgo de hospitalización por gripe: Estudio de casos y controles', Archivos de Bronconeumologia, vol. 52, no. 6, pp. 299-307. https://doi.org/10.1016/j.arbres.2015.11.006
Martín, Vicente ; Castilla, Jesús ; Godoy, Pere ; Delgado-Rodríguez, Miguel ; Soldevila, Nuria ; Fernández-Villa, Tania ; Molina, Antonio J. ; Astray, Jenaro ; Castro, Ady ; González-Candelas, Fernando ; Mayoral, José María ; Quintana, José María ; Domínguez, Ángela ; Azor, E. ; Carrillo, J. ; Moyano, R. ; Navarro, J. A. ; Vázquez, M. ; Zafra, F. ; Bueno, M. A. ; Delgado, M. ; Gómez, M. L. ; Mariscal, M. ; Martínez, B. ; Quesada, J. P. ; Sillero, M. ; Carnero, M. ; Fernández-Crehuet, J. ; del Diego Salas, J. ; Fuentes, V. ; Gallardo, V. ; Pérez, E. ; López, R. ; Maldonado, J. R. ; Morillo, A. ; Pedrosa Corral, I. ; Bautista, M. F. ; Navarro, J. M. ; Pérez, M. ; Oña, S. ; Pérez, M. J. ; Ubago, M. C. ; Zarzuela, M. ; Mayoral, J. M. ; González, F. ; Blanquer, J. ; Morales, M. ; Fernandez, T. ; Martín, V. ; Molina, A. ; Sanz, P. ; Carriedo, D. ; Díez, F. ; Fernández-Natal, I. ; Fernández, S. ; J.J. Castrodeza, Castrodeza ; Pérez, A. ; Tama-mes, S. ; Ortiz de Lejarazu, R. ; Ortiz de Saracho, J. ; Pueyo, A. ; Viejo, J. L. ; Redondo, P. ; Domínguez, A. ; Agustí, A. ; Torres, A. ; Trilla, A. ; Vilella, A. ; Barbé, F. ; Blanch, L. ; Navarro, G. ; Bonfill, X. ; López-Contreras, J. ; Pomar, V. ; Puig, M. T. ; Borràs, E. ; Martínez, N. ; Torner, A. ; Godoy, P. ; Bravo, C. ; Moraga, F. ; Calafell, F. ; Caylà, J. ; Tortajada, C. ; Garcia, J. ; Ruiz, I. ; J.J. García, García ; Baricot, M. ; Soldevila, N. ; Garín, O. ; Alonso, J. ; Gea, J. ; Horcajada, J. P. ; Pumarola, T. ; Hayes, N. ; Rosell, A. ; Dorca, J. ; Marc Saez, Saez ; álva-rez, C. ; Enríquez, M. ; Hernández Voth, A. ; Pozo, F. ; Baquero, F. ; Cantón, R. ; Galán, J. C. ; Robustillo, A. ; Valdeón, M. ; Astray, J. ; Córdoba, E. ; Domínguez, F. ; García Barquero, M. ; García, J. ; Génova, R. ; Gil, E. ; Jiménez, S. ; Lopaz, M. A. ; López, J. ; Martín, F. ; Martínez, M. L. ; Ordobás, M. ; Rodriguez, E. ; Sánchez, S. ; Valdés, C. ; J.R. Paño, Paño ; Romero, M. ; Castilla, J. ; Martínez, A. ; Martínez, L. ; Ruiz, M. ; Fanlo, P. ; Gil, F. ; Martínez-Artola, V. ; M.E. Ursua, Ursua ; Sota, M. ; Virto, M. T. ; Gamboa, J. ; Pérez-Afonso, F. ; Aguirre, U. ; Caspelastegui, A. ; España, P. P. ; García, S. ; Quintana, J. M. ; J.M. Antoñana, Antoñana ; Astigarraga, I. ; Pijoan, J. I. ; Pocheville, I. ; Santiago, M. ; Villate, J. I. ; Arístegui, J. ; Esco-bar, A. ; Garrote, M. I. ; Bilbao, A. ; Garaizar, C. ; Cilla, G. ; Korta, J. ; Pérez-Trallero, E. ; Sarasqueta, C. ; Aizpuru, F. ; Lobo, C. ; Salado, J. L. ; Alustiza, J. ; Troya, F. J. / Índice de masa corporal elevado como factor de riesgo de hospitalización por gripe : Estudio de casos y controles. In: Archivos de Bronconeumologia. 2016 ; Vol. 52, No. 6. pp. 299-307.
@article{a7309ec4429c4d679e093ba7c3a2d8bb,
title = "{\'I}ndice de masa corporal elevado como factor de riesgo de hospitalizaci{\'o}n por gripe: Estudio de casos y controles",
abstract = "Introduction: Obesity has emerged as a significant independent predictor of severity in pandemic influenza A (H1N1)pdm09. The aim of this study was to investigate the association between body mass index (BMI) and the risk of hospitalization due to influenza. Methods: Hospitalized patients (n = 755) with laboratory-confirmed influenza were individually matched by age, admission/visit date, and province with an outpatient (n = 783) with laboratory-confirmed influenza and an outpatient control (n = 950). We compared the BMI using conditional logistic regression adjusted for potential confounding factors (aOR). The population attributable fraction (PAF) was calculated. Results: A higher BMI was associated with an increased risk of hospitalization compared to both outpatient cases (aOR = 1.11; 95{\%} CI: 1.07-1.16) and outpatient controls (aOR = 1.04; 95{\%} CI: 1.01-1.07). Compared with normal weight, obesity type I, obesity type II and obesity type III was associated with a greater likelihood of hospitalization compared with outpatient cases (aOR = 1.85, 95{\%} CI: 1.05-3.26; aOR = 5.24, 95{\%} CI: 1.94-14.15 and aOR = 44.38, 95{\%} CI: 4.47-440.5). Compared with normal weight, obesity type II and obesity type III was associated with a greater likelihood of hospitalization compared with outpatient controls (aOR = 4.37, 95{\%} CI: 1.79-10.69 and aOR = 4.95, 95{\%} CI: 1.45-16.87). In persons without influenza vaccination, all categories of BMI ≥ 30 kg/m2 were associated with a greater likelihood of hospitalization compared with normal weight in both outpatient cases and outpatient controls. The PAF of hospitalization by influenza due to BMI ranged from 21.9{\%} to 8.5{\%}; in the case of unvaccinated against influenza between 20.5{\%} to 16.9{\%}. Conclusion: A high BMI is associated with an increased risk of hospitalization due to influenza. High percentage of hospital admissions are attributable to their BMI, especially in non vaccinated.",
keywords = "Body mass index, Case control study, Hospitalization risk, Influenza, Obesity, Population attributable fraction",
author = "Vicente Mart{\'i}n and Jes{\'u}s Castilla and Pere Godoy and Miguel Delgado-Rodr{\'i}guez and Nuria Soldevila and Tania Fern{\'a}ndez-Villa and Molina, {Antonio J.} and Jenaro Astray and Ady Castro and Fernando Gonz{\'a}lez-Candelas and Mayoral, {Jos{\'e} Mar{\'i}a} and Quintana, {Jos{\'e} Mar{\'i}a} and {\'A}ngela Dom{\'i}nguez and E. Azor and J. Carrillo and R. Moyano and Navarro, {J. A.} and M. V{\'a}zquez and F. Zafra and Bueno, {M. A.} and M. Delgado and G{\'o}mez, {M. L.} and M. Mariscal and B. Mart{\'i}nez and Quesada, {J. P.} and M. Sillero and M. Carnero and J. Fern{\'a}ndez-Crehuet and {del Diego Salas}, J. and V. Fuentes and V. Gallardo and E. P{\'e}rez and R. L{\'o}pez and Maldonado, {J. R.} and A. Morillo and {Pedrosa Corral}, I. and Bautista, {M. F.} and Navarro, {J. M.} and M. P{\'e}rez and S. O{\~n}a and P{\'e}rez, {M. J.} and Ubago, {M. C.} and M. Zarzuela and Mayoral, {J. M.} and F. Gonz{\'a}lez and J. Blanquer and M. Morales and T. Fernandez and V. Mart{\'i}n and A. Molina and P. Sanz and D. Carriedo and F. D{\'i}ez and I. Fern{\'a}ndez-Natal and S. Fern{\'a}ndez and {J.J. Castrodeza}, Castrodeza and A. P{\'e}rez and S. Tama-mes and {Ortiz de Lejarazu}, R. and {Ortiz de Saracho}, J. and A. Pueyo and Viejo, {J. L.} and P. Redondo and A. Dom{\'i}nguez and A. Agust{\'i} and A. Torres and A. Trilla and A. Vilella and F. Barb{\'e} and L. Blanch and G. Navarro and X. Bonfill and J. L{\'o}pez-Contreras and V. Pomar and Puig, {M. T.} and E. Borr{\`a}s and N. Mart{\'i}nez and A. Torner and P. Godoy and C. Bravo and F. Moraga and F. Calafell and J. Cayl{\`a} and C. Tortajada and J. Garcia and I. Ruiz and {J.J. Garc{\'i}a}, Garc{\'i}a and M. Baricot and N. Soldevila and O. Gar{\'i}n and J. Alonso and J. Gea and Horcajada, {J. P.} and T. Pumarola and N. Hayes and A. Rosell and J. Dorca and {Marc Saez}, Saez and C. {\'a}lva-rez and M. Enr{\'i}quez and {Hern{\'a}ndez Voth}, A. and F. Pozo and F. Baquero and R. Cant{\'o}n and Gal{\'a}n, {J. C.} and A. Robustillo and M. Valde{\'o}n and J. Astray and E. C{\'o}rdoba and F. Dom{\'i}nguez and {Garc{\'i}a Barquero}, M. and J. Garc{\'i}a and R. G{\'e}nova and E. Gil and S. Jim{\'e}nez and Lopaz, {M. A.} and J. L{\'o}pez and F. Mart{\'i}n and Mart{\'i}nez, {M. L.} and M. Ordob{\'a}s and E. Rodriguez and S. S{\'a}nchez and C. Vald{\'e}s and {J.R. Pa{\~n}o}, Pa{\~n}o and M. Romero and J. Castilla and A. Mart{\'i}nez and L. Mart{\'i}nez and M. Ruiz and P. Fanlo and F. Gil and V. Mart{\'i}nez-Artola and {M.E. Ursua}, Ursua and M. Sota and Virto, {M. T.} and J. Gamboa and F. P{\'e}rez-Afonso and U. Aguirre and A. Caspelastegui and Espa{\~n}a, {P. P.} and S. Garc{\'i}a and Quintana, {J. M.} and {J.M. Anto{\~n}ana}, Anto{\~n}ana and I. Astigarraga and Pijoan, {J. I.} and I. Pocheville and M. Santiago and Villate, {J. I.} and J. Ar{\'i}stegui and A. Esco-bar and Garrote, {M. I.} and A. Bilbao and C. Garaizar and G. Cilla and J. Korta and E. P{\'e}rez-Trallero and C. Sarasqueta and F. Aizpuru and C. Lobo and Salado, {J. L.} and J. Alustiza and Troya, {F. J.}",
year = "2016",
month = "6",
day = "1",
doi = "10.1016/j.arbres.2015.11.006",
language = "Spanish",
volume = "52",
pages = "299--307",
journal = "Archivos de Bronconeumologia",
issn = "0300-2896",
publisher = "Ediciones Doyma, S.L.",
number = "6",

}

TY - JOUR

T1 - Índice de masa corporal elevado como factor de riesgo de hospitalización por gripe

T2 - Estudio de casos y controles

AU - Martín, Vicente

AU - Castilla, Jesús

AU - Godoy, Pere

AU - Delgado-Rodríguez, Miguel

AU - Soldevila, Nuria

AU - Fernández-Villa, Tania

AU - Molina, Antonio J.

AU - Astray, Jenaro

AU - Castro, Ady

AU - González-Candelas, Fernando

AU - Mayoral, José María

AU - Quintana, José María

AU - Domínguez, Ángela

AU - Azor, E.

AU - Carrillo, J.

AU - Moyano, R.

AU - Navarro, J. A.

AU - Vázquez, M.

AU - Zafra, F.

AU - Bueno, M. A.

AU - Delgado, M.

AU - Gómez, M. L.

AU - Mariscal, M.

AU - Martínez, B.

AU - Quesada, J. P.

AU - Sillero, M.

AU - Carnero, M.

AU - Fernández-Crehuet, J.

AU - del Diego Salas, J.

AU - Fuentes, V.

AU - Gallardo, V.

AU - Pérez, E.

AU - López, R.

AU - Maldonado, J. R.

AU - Morillo, A.

AU - Pedrosa Corral, I.

AU - Bautista, M. F.

AU - Navarro, J. M.

AU - Pérez, M.

AU - Oña, S.

AU - Pérez, M. J.

AU - Ubago, M. C.

AU - Zarzuela, M.

AU - Mayoral, J. M.

AU - González, F.

AU - Blanquer, J.

AU - Morales, M.

AU - Fernandez, T.

AU - Martín, V.

AU - Molina, A.

AU - Sanz, P.

AU - Carriedo, D.

AU - Díez, F.

AU - Fernández-Natal, I.

AU - Fernández, S.

AU - J.J. Castrodeza, Castrodeza

AU - Pérez, A.

AU - Tama-mes, S.

AU - Ortiz de Lejarazu, R.

AU - Ortiz de Saracho, J.

AU - Pueyo, A.

AU - Viejo, J. L.

AU - Redondo, P.

AU - Domínguez, A.

AU - Agustí, A.

AU - Torres, A.

AU - Trilla, A.

AU - Vilella, A.

AU - Barbé, F.

AU - Blanch, L.

AU - Navarro, G.

AU - Bonfill, X.

AU - López-Contreras, J.

AU - Pomar, V.

AU - Puig, M. T.

AU - Borràs, E.

AU - Martínez, N.

AU - Torner, A.

AU - Godoy, P.

AU - Bravo, C.

AU - Moraga, F.

AU - Calafell, F.

AU - Caylà, J.

AU - Tortajada, C.

AU - Garcia, J.

AU - Ruiz, I.

AU - J.J. García, García

AU - Baricot, M.

AU - Soldevila, N.

AU - Garín, O.

AU - Alonso, J.

AU - Gea, J.

AU - Horcajada, J. P.

AU - Pumarola, T.

AU - Hayes, N.

AU - Rosell, A.

AU - Dorca, J.

AU - Marc Saez, Saez

AU - álva-rez, C.

AU - Enríquez, M.

AU - Hernández Voth, A.

AU - Pozo, F.

AU - Baquero, F.

AU - Cantón, R.

AU - Galán, J. C.

AU - Robustillo, A.

AU - Valdeón, M.

AU - Astray, J.

AU - Córdoba, E.

AU - Domínguez, F.

AU - García Barquero, M.

AU - García, J.

AU - Génova, R.

AU - Gil, E.

AU - Jiménez, S.

AU - Lopaz, M. A.

AU - López, J.

AU - Martín, F.

AU - Martínez, M. L.

AU - Ordobás, M.

AU - Rodriguez, E.

AU - Sánchez, S.

AU - Valdés, C.

AU - J.R. Paño, Paño

AU - Romero, M.

AU - Castilla, J.

AU - Martínez, A.

AU - Martínez, L.

AU - Ruiz, M.

AU - Fanlo, P.

AU - Gil, F.

AU - Martínez-Artola, V.

AU - M.E. Ursua, Ursua

AU - Sota, M.

AU - Virto, M. T.

AU - Gamboa, J.

AU - Pérez-Afonso, F.

AU - Aguirre, U.

AU - Caspelastegui, A.

AU - España, P. P.

AU - García, S.

AU - Quintana, J. M.

AU - J.M. Antoñana, Antoñana

AU - Astigarraga, I.

AU - Pijoan, J. I.

AU - Pocheville, I.

AU - Santiago, M.

AU - Villate, J. I.

AU - Arístegui, J.

AU - Esco-bar, A.

AU - Garrote, M. I.

AU - Bilbao, A.

AU - Garaizar, C.

AU - Cilla, G.

AU - Korta, J.

AU - Pérez-Trallero, E.

AU - Sarasqueta, C.

AU - Aizpuru, F.

AU - Lobo, C.

AU - Salado, J. L.

AU - Alustiza, J.

AU - Troya, F. J.

PY - 2016/6/1

Y1 - 2016/6/1

N2 - Introduction: Obesity has emerged as a significant independent predictor of severity in pandemic influenza A (H1N1)pdm09. The aim of this study was to investigate the association between body mass index (BMI) and the risk of hospitalization due to influenza. Methods: Hospitalized patients (n = 755) with laboratory-confirmed influenza were individually matched by age, admission/visit date, and province with an outpatient (n = 783) with laboratory-confirmed influenza and an outpatient control (n = 950). We compared the BMI using conditional logistic regression adjusted for potential confounding factors (aOR). The population attributable fraction (PAF) was calculated. Results: A higher BMI was associated with an increased risk of hospitalization compared to both outpatient cases (aOR = 1.11; 95% CI: 1.07-1.16) and outpatient controls (aOR = 1.04; 95% CI: 1.01-1.07). Compared with normal weight, obesity type I, obesity type II and obesity type III was associated with a greater likelihood of hospitalization compared with outpatient cases (aOR = 1.85, 95% CI: 1.05-3.26; aOR = 5.24, 95% CI: 1.94-14.15 and aOR = 44.38, 95% CI: 4.47-440.5). Compared with normal weight, obesity type II and obesity type III was associated with a greater likelihood of hospitalization compared with outpatient controls (aOR = 4.37, 95% CI: 1.79-10.69 and aOR = 4.95, 95% CI: 1.45-16.87). In persons without influenza vaccination, all categories of BMI ≥ 30 kg/m2 were associated with a greater likelihood of hospitalization compared with normal weight in both outpatient cases and outpatient controls. The PAF of hospitalization by influenza due to BMI ranged from 21.9% to 8.5%; in the case of unvaccinated against influenza between 20.5% to 16.9%. Conclusion: A high BMI is associated with an increased risk of hospitalization due to influenza. High percentage of hospital admissions are attributable to their BMI, especially in non vaccinated.

AB - Introduction: Obesity has emerged as a significant independent predictor of severity in pandemic influenza A (H1N1)pdm09. The aim of this study was to investigate the association between body mass index (BMI) and the risk of hospitalization due to influenza. Methods: Hospitalized patients (n = 755) with laboratory-confirmed influenza were individually matched by age, admission/visit date, and province with an outpatient (n = 783) with laboratory-confirmed influenza and an outpatient control (n = 950). We compared the BMI using conditional logistic regression adjusted for potential confounding factors (aOR). The population attributable fraction (PAF) was calculated. Results: A higher BMI was associated with an increased risk of hospitalization compared to both outpatient cases (aOR = 1.11; 95% CI: 1.07-1.16) and outpatient controls (aOR = 1.04; 95% CI: 1.01-1.07). Compared with normal weight, obesity type I, obesity type II and obesity type III was associated with a greater likelihood of hospitalization compared with outpatient cases (aOR = 1.85, 95% CI: 1.05-3.26; aOR = 5.24, 95% CI: 1.94-14.15 and aOR = 44.38, 95% CI: 4.47-440.5). Compared with normal weight, obesity type II and obesity type III was associated with a greater likelihood of hospitalization compared with outpatient controls (aOR = 4.37, 95% CI: 1.79-10.69 and aOR = 4.95, 95% CI: 1.45-16.87). In persons without influenza vaccination, all categories of BMI ≥ 30 kg/m2 were associated with a greater likelihood of hospitalization compared with normal weight in both outpatient cases and outpatient controls. The PAF of hospitalization by influenza due to BMI ranged from 21.9% to 8.5%; in the case of unvaccinated against influenza between 20.5% to 16.9%. Conclusion: A high BMI is associated with an increased risk of hospitalization due to influenza. High percentage of hospital admissions are attributable to their BMI, especially in non vaccinated.

KW - Body mass index

KW - Case control study

KW - Hospitalization risk

KW - Influenza

KW - Obesity

KW - Population attributable fraction

UR - http://www.scopus.com/inward/record.url?scp=84956894866&partnerID=8YFLogxK

UR - http://www.scopus.com/inward/citedby.url?scp=84956894866&partnerID=8YFLogxK

U2 - 10.1016/j.arbres.2015.11.006

DO - 10.1016/j.arbres.2015.11.006

M3 - Article

VL - 52

SP - 299

EP - 307

JO - Archivos de Bronconeumologia

JF - Archivos de Bronconeumologia

SN - 0300-2896

IS - 6

ER -