High basal expression of zif268 in cortex is dependent on intact noradrenergic system

Ratan V. Bhat, Jay M. Baraban

Research output: Contribution to journalArticle

Abstract

The transcription factor Zif268 displays high basal levels of expression in cortex that appear to be dependent on physiological synaptic activity. We report that selective lesions of the noradrenergic system induced by DSP4 markedly suppress basal zif268 mRNA levels in cortex. Accordingly, the noradrenergic system which projects extensively to the cortex and is tonically active may play a key role in maintaining normal patterns of gene expression in target neurons.

Original languageEnglish (US)
Pages (from-to)447-448
Number of pages2
JournalEuropean Journal of Pharmacology: Molecular Pharmacology
Volume227
Issue number4
DOIs
StatePublished - Dec 1 1992

Keywords

  • DSP4 (N-(2-chloroethyl)-N-ethyl-2-bromobenzylamine)
  • Locus coeruleus
  • Transcription factors

ASJC Scopus subject areas

  • Pharmacology

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