HIF2A gain-of-function mutation modulates the stiffness of smooth muscle cells and compromises vascular mechanics

Xin Yi Chan; Eugenia Volkova; Joon Eoh; Rebecca Black; Lilly Fang; Rayyan Gorashi; Jihyun Song; Jing Wang; Morgan B. Elliott; Sebastian F. Barreto-Ortiz; James Chen; Brian L. Lin; Lakshmi Santhanam; Linzhao Cheng; Frank S. Lee; Josef T. Prchal; Sharon Gerecht

doi:10.1016/j.isci.2021.102246

HIF2A gain-of-function mutation modulates the stiffness of smooth muscle cells and compromises vascular mechanics

Xin Yi Chan, Eugenia Volkova, Joon Eoh, Rebecca Black, Lilly Fang, Rayyan Gorashi, Jihyun Song, Jing Wang, Morgan B. Elliott, Sebastian F. Barreto-Ortiz, James Chen, Brian L. Lin, Lakshmi Santhanam, Linzhao Cheng, Frank S. Lee, Josef T. Prchal, Sharon Gerecht

Research output: Contribution to journal › Article › peer-review

Abstract

Pathophysiology;

Original language	English (US)
Article number	102246
Journal	iScience
Volume	24
Issue number	4
DOIs	https://doi.org/10.1016/j.isci.2021.102246
State	Published - Apr 23 2021

Keywords

Biomechanics
Biophysics
Pathophysiology

ASJC Scopus subject areas

General

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10.1016/j.isci.2021.102246

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Chan, X. Y., Volkova, E., Eoh, J., Black, R., Fang, L., Gorashi, R., Song, J., Wang, J., Elliott, M. B., Barreto-Ortiz, S. F., Chen, J., Lin, B. L., Santhanam, L., Cheng, L., Lee, F. S., Prchal, J. T., & Gerecht, S. (2021). HIF2A gain-of-function mutation modulates the stiffness of smooth muscle cells and compromises vascular mechanics. iScience, 24(4), Article 102246. https://doi.org/10.1016/j.isci.2021.102246

Chan, XY, Volkova, E, Eoh, J, Black, R, Fang, L, Gorashi, R, Song, J, Wang, J, Elliott, MB, Barreto-Ortiz, SF, Chen, J, Lin, BL, Santhanam, L, Cheng, L, Lee, FS, Prchal, JT & Gerecht, S 2021, 'HIF2A gain-of-function mutation modulates the stiffness of smooth muscle cells and compromises vascular mechanics', iScience, vol. 24, no. 4, 102246. https://doi.org/10.1016/j.isci.2021.102246

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title = "HIF2A gain-of-function mutation modulates the stiffness of smooth muscle cells and compromises vascular mechanics",

abstract = "Pathophysiology;",

keywords = "Biomechanics, Biophysics, Pathophysiology",

author = "Chan, {Xin Yi} and Eugenia Volkova and Joon Eoh and Rebecca Black and Lilly Fang and Rayyan Gorashi and Jihyun Song and Jing Wang and Elliott, {Morgan B.} and Barreto-Ortiz, {Sebastian F.} and James Chen and Lin, {Brian L.} and Lakshmi Santhanam and Linzhao Cheng and Lee, {Frank S.} and Prchal, {Josef T.} and Sharon Gerecht",

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year = "2021",

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doi = "10.1016/j.isci.2021.102246",

language = "English (US)",

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TY - JOUR

T1 - HIF2A gain-of-function mutation modulates the stiffness of smooth muscle cells and compromises vascular mechanics

AU - Chan, Xin Yi

AU - Volkova, Eugenia

AU - Eoh, Joon

AU - Black, Rebecca

AU - Fang, Lilly

AU - Gorashi, Rayyan

AU - Song, Jihyun

AU - Wang, Jing

AU - Elliott, Morgan B.

AU - Barreto-Ortiz, Sebastian F.

AU - Chen, James

AU - Lin, Brian L.

AU - Santhanam, Lakshmi

AU - Cheng, Linzhao

AU - Lee, Frank S.

AU - Prchal, Josef T.

AU - Gerecht, Sharon

PY - 2021/4/23

Y1 - 2021/4/23

N2 - Pathophysiology;

AB - Pathophysiology;

KW - Biomechanics

KW - Biophysics

KW - Pathophysiology

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U2 - 10.1016/j.isci.2021.102246

DO - 10.1016/j.isci.2021.102246

M3 - Article

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AN - SCOPUS:85102565837

SN - 2589-0042

VL - 24

JO - iScience

JF - iScience

IS - 4

M1 - 102246

ER -

HIF2A gain-of-function mutation modulates the stiffness of smooth muscle cells and compromises vascular mechanics

Abstract

Keywords

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