HIF-1: upstream and downstream of cancer metabolism

Research output: Contribution to journalReview articlepeer-review

Abstract

Hypoxia-inducible factor 1 (HIF-1) plays a key role in the reprogramming of cancer metabolism by activating transcription of genes encoding glucose transporters and glycolytic enzymes, which take up glucose and convert it to lactate; pyruvate dehydrogenase kinase 1, which shunts pyruvate away from the mitochondria; and BNIP3, which triggers selective mitochondrial autophagy. The shift from oxidative to glycolytic metabolism allows maintenance of redox homeostasis and cell survival under conditions of prolonged hypoxia. Many metabolic abnormalities in cancer cells increase HIF-1 activity. As a result, a feed-forward mechanism can be activated that drives HIF-1 activation and may promote tumor progression.

Original languageEnglish (US)
Pages (from-to)51-56
Number of pages6
JournalCurrent Opinion in Genetics and Development
Volume20
Issue number1
DOIs
StatePublished - Feb 1 2010

ASJC Scopus subject areas

  • Genetics
  • Developmental Biology

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