HIF-1, O2, and the 3 PHDs: How animal cells signal hypoxia to the nucleus

Research output: Contribution to journalReview article

Abstract

Hypoxia-inducible factor 1 (HIF-1) is a global regulator of cellular and systemic O2 homeostasis in animals. A molecular basis for O2-regulated expression of the HIF-1α subunit has now been determined, providing a mechanism for changes in gene expression in response to changes in cellular oxygenation.

Original languageEnglish (US)
Pages (from-to)1-3
Number of pages3
JournalCell
Volume107
Issue number1
DOIs
StatePublished - Oct 5 2001

ASJC Scopus subject areas

  • Biochemistry, Genetics and Molecular Biology(all)

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