HIF-1 and mechanisms of hypoxia sensing

Research output: Contribution to journalReview article

Abstract

Hypoxia-inducible factor 1 (HIF-1) is an oxygen-regulated transcriptional activator that plays essential roles in mammalian development, physiology and disease pathogenesis. The HIF-1α subunit is subjected to oxygen-dependent ubiquitination and proteasomal degradation that is mediated by the von Hippel-Lindau protein. Interaction of HIF-1α transactivation domains with coactivators is induced by hypoxia. The signal transduction pathway remains enigmatic, but involves generation of reactive oxygen species. Nitric oxide induces HIF-1α under non-hypoxic conditions but inhibits hypoxia-induced HIF-1α expression.

Original languageEnglish (US)
Pages (from-to)167-171
Number of pages5
JournalCurrent Opinion in Cell Biology
Volume13
Issue number2
DOIs
StatePublished - Apr 1 2001

ASJC Scopus subject areas

  • Cell Biology

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