Abstract
Hypoxia-inducible factor 1 (HIF-1) is an oxygen-regulated transcriptional activator that plays essential roles in mammalian development, physiology and disease pathogenesis. The HIF-1α subunit is subjected to oxygen-dependent ubiquitination and proteasomal degradation that is mediated by the von Hippel-Lindau protein. Interaction of HIF-1α transactivation domains with coactivators is induced by hypoxia. The signal transduction pathway remains enigmatic, but involves generation of reactive oxygen species. Nitric oxide induces HIF-1α under non-hypoxic conditions but inhibits hypoxia-induced HIF-1α expression.
Original language | English (US) |
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Pages (from-to) | 167-171 |
Number of pages | 5 |
Journal | Current Opinion in Cell Biology |
Volume | 13 |
Issue number | 2 |
DOIs | |
State | Published - Apr 1 2001 |
ASJC Scopus subject areas
- Cell Biology