TY - JOUR
T1 - HGPRT in the Gilles de la Tourette Syndrome
AU - Johnson, Gerald G.
AU - Pepple, James M.
AU - Singer, Harvey S.
AU - Littlefield, John W.
PY - 1977/8/11
Y1 - 1977/8/11
N2 - To the Editor: Van Woert, Yip and Balis1 report an alteration in the isoelectric focusing of the enzyme hypoxanthine-guanine phosphoribosyltransferase, E.C.2.4.2.8 (HGPRT), in red-cell lysates of patients affected with the Gilles de la Tourette syndrome. Because of similarities to the X-chromosome-linked HGPRT deficiency syndrome (Lesch-Nyhan), males being more frequently affected than females and some patients having a clinical history of self-mutilation,2 the authors interpret their results as providing evidence that purine metabolism is abnormal in these cases. We have examined the isoelectric focusing properties of HGPRT in red-cell lysates of six unrelated male patients with the Gilles de la Tourette.
AB - To the Editor: Van Woert, Yip and Balis1 report an alteration in the isoelectric focusing of the enzyme hypoxanthine-guanine phosphoribosyltransferase, E.C.2.4.2.8 (HGPRT), in red-cell lysates of patients affected with the Gilles de la Tourette syndrome. Because of similarities to the X-chromosome-linked HGPRT deficiency syndrome (Lesch-Nyhan), males being more frequently affected than females and some patients having a clinical history of self-mutilation,2 the authors interpret their results as providing evidence that purine metabolism is abnormal in these cases. We have examined the isoelectric focusing properties of HGPRT in red-cell lysates of six unrelated male patients with the Gilles de la Tourette.
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U2 - 10.1056/NEJM197708112970619
DO - 10.1056/NEJM197708112970619
M3 - Letter
C2 - 267247
AN - SCOPUS:0017772654
SN - 0028-4793
VL - 297
SP - 339
JO - New England Journal of Medicine
JF - New England Journal of Medicine
IS - 6
ER -