HGPRT in the Gilles de la Tourette Syndrome

Gerald G. Johnson, James M. Pepple, Harvey S. Singer, John W. Littlefield

Research output: Contribution to journalLetterpeer-review

Abstract

To the Editor: Van Woert, Yip and Balis1 report an alteration in the isoelectric focusing of the enzyme hypoxanthine-guanine phosphoribosyltransferase, E.C.2.4.2.8 (HGPRT), in red-cell lysates of patients affected with the Gilles de la Tourette syndrome. Because of similarities to the X-chromosome-linked HGPRT deficiency syndrome (Lesch-Nyhan), males being more frequently affected than females and some patients having a clinical history of self-mutilation,2 the authors interpret their results as providing evidence that purine metabolism is abnormal in these cases. We have examined the isoelectric focusing properties of HGPRT in red-cell lysates of six unrelated male patients with the Gilles de la Tourette.

Original languageEnglish (US)
Number of pages1
JournalNew England Journal of Medicine
Volume297
Issue number6
DOIs
StatePublished - Aug 11 1977

ASJC Scopus subject areas

  • Medicine(all)

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