Heterozygous VMAT2 knockout mice display prolonged QT intervals: Possible contributions to sudden death

Kaori Itokawa, Ichiro Sora, Charles W. Schindler, Masanari Itokawa, Nobuyuki Takahashi, George R. Uhl

Research output: Contribution to journalArticlepeer-review

Abstract

Heterozygous knockout (KO) mice with half of wild-type levels of expression of the vesicular monoamine transporter (VMAT2) can suddenly die in midlife. To seek mechanisms for this sudden death, we have examined electrocardiogram (ECG) data telemetered from freely-moving heterozygote and wild-type littermate mice. Many ECG parameters were indistinguishable in mice of these two strains. However, heterozygous mice displayed prolonged QT intervals. These findings provide likely contributions to differences in vulnerability to lethal arrhythmias in these animals, and a candidate gene for contributions to human interindividual differences in vulnerability to cardiac arrhythmias.

Original languageEnglish (US)
Pages (from-to)354-357
Number of pages4
JournalMolecular Brain Research
Volume71
Issue number2
DOIs
StatePublished - Aug 25 1999

Keywords

  • Electrocardiogram
  • Prolonged QT
  • Telemetry
  • Transgenic mouse
  • Vesicular monoamine transporter 2

ASJC Scopus subject areas

  • Molecular Biology
  • Cellular and Molecular Neuroscience

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