TY - JOUR
T1 - Heterozygous VMAT2 knockout mice display prolonged QT intervals
T2 - Possible contributions to sudden death
AU - Itokawa, Kaori
AU - Sora, Ichiro
AU - Schindler, Charles W.
AU - Itokawa, Masanari
AU - Takahashi, Nobuyuki
AU - Uhl, George R.
PY - 1999/8/25
Y1 - 1999/8/25
N2 - Heterozygous knockout (KO) mice with half of wild-type levels of expression of the vesicular monoamine transporter (VMAT2) can suddenly die in midlife. To seek mechanisms for this sudden death, we have examined electrocardiogram (ECG) data telemetered from freely-moving heterozygote and wild-type littermate mice. Many ECG parameters were indistinguishable in mice of these two strains. However, heterozygous mice displayed prolonged QT intervals. These findings provide likely contributions to differences in vulnerability to lethal arrhythmias in these animals, and a candidate gene for contributions to human interindividual differences in vulnerability to cardiac arrhythmias.
AB - Heterozygous knockout (KO) mice with half of wild-type levels of expression of the vesicular monoamine transporter (VMAT2) can suddenly die in midlife. To seek mechanisms for this sudden death, we have examined electrocardiogram (ECG) data telemetered from freely-moving heterozygote and wild-type littermate mice. Many ECG parameters were indistinguishable in mice of these two strains. However, heterozygous mice displayed prolonged QT intervals. These findings provide likely contributions to differences in vulnerability to lethal arrhythmias in these animals, and a candidate gene for contributions to human interindividual differences in vulnerability to cardiac arrhythmias.
KW - Electrocardiogram
KW - Prolonged QT
KW - Telemetry
KW - Transgenic mouse
KW - Vesicular monoamine transporter 2
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U2 - 10.1016/S0169-328X(99)00194-1
DO - 10.1016/S0169-328X(99)00194-1
M3 - Article
C2 - 10521591
AN - SCOPUS:0032695413
SN - 0169-328X
VL - 71
SP - 354
EP - 357
JO - Molecular Brain Research
JF - Molecular Brain Research
IS - 2
ER -