Heterozygous Toll-Like Receptor 2 Polymorphism Does Not Affect Lipoteichoic Acid-Induced Chemokine and Inflammatory Responses

Sonja Von Aulock, Nicolas W.J. Schröder, Stephanie Traub, Katja Gueinzius, Eva Lorenz, Thomas Hartung, Ralf R. Schumann, Corinna Hermann

Research output: Contribution to journalArticlepeer-review

Abstract

While transfection of tlr2 conveyed responsiveness to lipoteichoic acid (LTA), the Arg753Gln polymorphic gene could not. LTA induced a stronger chemokine and anti-inflammatory response than lipopolysaccharides did. Blood from heterozygous polymorphic and wild-type donors reacted uniformly to LTA and Staphylococcus aureus. Thus, one functional allele for Toll-like receptor 2 suffices for full cytokine response.

Original languageEnglish (US)
Pages (from-to)1828-1831
Number of pages4
JournalInfection and immunity
Volume72
Issue number3
DOIs
StatePublished - Mar 2004
Externally publishedYes

ASJC Scopus subject areas

  • Parasitology
  • Microbiology
  • Immunology
  • Infectious Diseases

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