Heterotransplantation of malignant human gliomas in neonatal rats

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Abstract

Three human glioma cell lines (TE-671 medulloblastoma, U-87 MG glioblastoma, and U-373 MG glioblastoma) were transplanted to the quadrigeminal cistern of the brain in 37 newborn Sprague-Dawley rats and to the subcutaneous space in 30 of their siblings. Two of the three gliomas (the TE-671 medulloblastoma and the U-87 MG glioblastoma) grew both intracranially and subcutaneously. The U-373 MG glioblastoma did not grow in either site. The resulting tumors expressed unique morphological features characteristic of their tissue of origin. The newborn rat represents a model for the heterologous transplantation of human gliomas, providing a biological window for the study of these lesions.

Original languageEnglish (US)
Pages (from-to)928-933
Number of pages6
JournalJournal of Neurosurgery
Volume69
Issue number6
StatePublished - 1988

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ASJC Scopus subject areas

  • Clinical Neurology
  • Neuroscience(all)

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