Heterologous prime/boost immunizations of rhesus monkeys using chimpanzee adenovirus vectors

Sampa Santra, Yue Sun, Birgit Korioth-Schmitz, Julie Fitzgerald, Cherie Charbonneau, Giannina Santos, Michael S. Seaman, Sarah J. Ratcliffe, David C. Montefiori, Gary J. Nabel, Hildegund C J Ertl, Norman L. Letvin

Research output: Contribution to journalArticlepeer-review

Abstract

Pre-existing immunity to human adenovirus serotype 5 (AdHu5) has been shown to suppress the immunogenicity of recombinant Ad5 (rAdHu5) vector-based vaccines for human immunodeficiency virus type 1 (HIV-1) in both preclinical studies and clinical trials. As a potential solution to this problem we developed adenovirus vaccine vectors of chimpanzee origin. In the present study we assessed the immunogenicity of various chimpanzee adenovirus vectors in a prime/boost regimen to HIV-1 envelope and SIV Gag-Pol in rhesus monkeys and their ability to protect against pathogenic viral challenge. Although rAdHu5-primed monkeys had higher magnitude T cell responses than rAdC7 or rAdC68 prior to challenge, the rAdC7-rAdC1/C5 and rAdHu5-rAdC1/C5 immunizations resulted in comparable magnitude recall cellular immune responses and comparable level of control of viremia post-challenge.

Original languageEnglish (US)
Pages (from-to)5837-5845
Number of pages9
JournalVaccine
Volume27
Issue number42
DOIs
StatePublished - Sep 25 2009
Externally publishedYes

Keywords

  • Chimpanzee adenovirus
  • HIV-1 vaccine

ASJC Scopus subject areas

  • Immunology and Microbiology(all)
  • Infectious Diseases
  • Public Health, Environmental and Occupational Health
  • veterinary(all)
  • Molecular Medicine

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