Heterogeneous nucleation of calcium oxalate crystals in mammalian urine

S. R. Khan, G. H. Nancollas, A. Boskey, W. Achilles, R. Ryall

Research output: Contribution to journalArticle

Abstract

It is generally recognized that calcium oxalate crystal formation in urine is induced by heterogeneous nucleation. However, there is no consensus as to the nature of the nucleation substrate. Evidence is provided in this paper that membranous cellular degradation products are the most likely candidates because they: (1) are ubiquitous in urine and urinary stones; (2) are found in close association with crystal deposits in the kidneys; and (3) can induce nucleation of crystals from a metastable solution of calcium oxalate in vitro and metastable urine in vivo.

Original languageEnglish (US)
Pages (from-to)597-616
Number of pages20
JournalScanning Microscopy
Volume9
Issue number2
StatePublished - 1995
Externally publishedYes

Fingerprint

urine
oxalates
calcium
Calcium
Nucleation
nucleation
Crystals
crystals
kidneys
Deposits
deposits
Association reactions
rocks
degradation
Degradation
Substrates
products

Keywords

  • Calcium oxalate
  • calcium phosphate
  • cell membrane
  • matrix vesicles
  • mineralization
  • nephrolithiasis
  • urolithiasis

ASJC Scopus subject areas

  • Instrumentation

Cite this

Khan, S. R., Nancollas, G. H., Boskey, A., Achilles, W., & Ryall, R. (1995). Heterogeneous nucleation of calcium oxalate crystals in mammalian urine. Scanning Microscopy, 9(2), 597-616.

Heterogeneous nucleation of calcium oxalate crystals in mammalian urine. / Khan, S. R.; Nancollas, G. H.; Boskey, A.; Achilles, W.; Ryall, R.

In: Scanning Microscopy, Vol. 9, No. 2, 1995, p. 597-616.

Research output: Contribution to journalArticle

Khan, SR, Nancollas, GH, Boskey, A, Achilles, W & Ryall, R 1995, 'Heterogeneous nucleation of calcium oxalate crystals in mammalian urine', Scanning Microscopy, vol. 9, no. 2, pp. 597-616.
Khan SR, Nancollas GH, Boskey A, Achilles W, Ryall R. Heterogeneous nucleation of calcium oxalate crystals in mammalian urine. Scanning Microscopy. 1995;9(2):597-616.
Khan, S. R. ; Nancollas, G. H. ; Boskey, A. ; Achilles, W. ; Ryall, R. / Heterogeneous nucleation of calcium oxalate crystals in mammalian urine. In: Scanning Microscopy. 1995 ; Vol. 9, No. 2. pp. 597-616.
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