Heterogeneity of viral IL-6 expression in HHV-8-associated diseases

Jennifer S. Cannon, John Nicholas, Jan M. Orenstein, Risa B. Mann, Paul G. Murray, Philip J. Browning, Joseph A. DiGiuseppe, Ethel Cesarman, Gary S. Hayward, Richard F. Ambinder

Research output: Contribution to journalArticlepeer-review

Abstract

In order to characterize the expression of the viral interleukin-6 (vIL- 6) homologue in various human herpesvirus 8 (HHV-8)-associated diseases, in situ hybridization and immunohistochemistry were applied to formalin-fixed specimens. These assays showed consistent expression of vIL-6 in primary effusion lymphomas and in a case of human immunodeficiency virus (HIV)- associated lymphadenopathy with a Castleman's disease-like appearance. In contrast, Kaposi's sarcoma specimens showed marked differences among specimens. In a consecutive series of specimens from the Johns Hopkins archives, vIL-6 expression was demonstrated in one of 13 cases. However, among 7 specimens selected from the AIDS Malignancy Bank because of their high levels of the T1.1 lytic transcript and virion production, vIL-6 expression was consistently demonstrated in infiltrating mononuclear cells and occasional spindle-shaped cells. Thus vIL-6 expression in clinical specimens correlates with other measures of the lytic viral cycle. Both assays generally give congruent results and are consistent with the possibility that vIL-6 expression plays a role in the pathogenesis of a variety of HHV-8-associated diseases.

Original languageEnglish (US)
Pages (from-to)824-828
Number of pages5
JournalJournal of Infectious Diseases
Volume180
Issue number3
DOIs
StatePublished - 1999

ASJC Scopus subject areas

  • Immunology and Allergy
  • Infectious Diseases

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