Heterogeneity of stimulant dependence: A national drug abuse treatment clinical trials network study

Li Tzy Wu, Dan G. Blazer, Ashwin A. Patkar, Maxine L. Stitzer, Paul G. Wakim, Robert K. Brooner

Research output: Contribution to journalArticlepeer-review

Abstract

We investigated the presence of DSM-IV subtyping for dependence on cocaine and amphetamines (with versus without physical dependence) among outpatient stimulant users enrolled in a multisite study of the Clinical Trials Network (CTN). Three mutually exclusive groups were identified: primary cocaine users (n = 287), primary amphetamine users (n = 99), and dual users (cocaine and amphetamines; n = 29). Distinct subtypes were examined with latent class and logistic regression procedures. Cocaine users were distinct from amphetamine users in age and race/ethnicity. There were four distinct classes of primary cocaine users: non-dependence (15%), compulsive use (14%), tolerance and compulsive use (15%), and physiological dependence (tolerance, withdrawal, and compulsive use; 56%). Three distinct classes of primary amphetamine users were identified: non-dependence (11%), intermediate physiological dependence (31%), and physiological dependence (58%). Regardless of stimulants used, most female users were in the most severe or the physiological dependence group. These results lend support for subtyping dependence in the emerging DSM-V.

Original languageEnglish (US)
Pages (from-to)206-218
Number of pages13
JournalAmerican Journal on Addictions
Volume18
Issue number3
DOIs
StatePublished - May 2009

ASJC Scopus subject areas

  • Medicine (miscellaneous)
  • Clinical Psychology
  • Psychiatry and Mental health

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