Heterogeneity of SPECT Bull's-eyes in Normal Dogs: Comparison of Attenuation Compensation Algorithms

E. V.R. DiBella, R. L. Eisner, L. S. Schmarkey, A. B. Barclay, R. E. Patterson, D. J. Nowak, D. S. Lalush, B. M.W. Tsui

Research output: Contribution to journalArticlepeer-review


In normal dogs, SPECT 99mTc Sestamibi (MIBI) and 201Tl myocardial perfusion images reconstructed with filtered backprojection (FBP) show a large decrease of counts in the septal wall (S) compared to the lateral wall (L). We evaluated the iterative method of Chang at 0 and 1 iterations (Chang0 and Chang1), and the Maximum Likelihood-Expectation Maximization with attenuation compensation (ML-EM-ATN) algorithm on data acquired from 5 normal dogs and from simulated projection data using a homogeneous count-density model of a normal canine myocardium in the attenuation field measured in one dog. Mean counts in the S and L regions were calculated from maximum-count circumferential profile arrays. The table shows mean ± s.d. S/L count ratios. Our results demonstrate that ML-EM-ATN and Chang1 result in improved uniformity, as measured by the S/L ratio.

Original languageEnglish (US)
Pages (from-to)1290-1296
Number of pages7
JournalIEEE Transactions on Nuclear Science
Issue number4
StatePublished - Aug 1995
Externally publishedYes

ASJC Scopus subject areas

  • Nuclear and High Energy Physics
  • Nuclear Energy and Engineering
  • Electrical and Electronic Engineering


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