TY - JOUR
T1 - Heterogeneity in rate of decline in grip, hip, and knee strength and the risk of all-cause mortality
T2 - The women's health and aging study II
AU - Xue, Qian Li
AU - Beamer, Brock A.
AU - Chaves, Paulo H.M.
AU - Guralnik, Jack M.
AU - Fried, Linda P.
PY - 2010/11
Y1 - 2010/11
N2 - OBJECTIVES: To assess the relationship between rate of change in muscle strength and all-cause mortality. DESIGN: Prospective observational study of the causes and course of physical disability. SETTING: Twelve contiguous ZIP code areas in Baltimore, Maryland. PARTICIPANTS: Three hundred seven community-dwelling women aged 70 to 79 at study baseline. MEASUREMENTS: The outcome was all-cause mortality (1994-2009); predictors included up to seven repeated measurements of handgrip, knee extension, and hip flexion strength, with a median follow-up time of 10 years. Demographic factors, body mass index, smoking status, number of chronic diseases, depressive symptoms, physical activity, interleukin-6, and albumin were assessed at baseline and included as confounders. The associations between declining muscle strength and mortality were assessed using a joint longitudinal and survival model. RESULTS: Grip and hip strength declined an average of 1.10 and 1.31 kg/year between age 70 and 75 and 0.50 and 0.39 kg/year thereafter, respectively; knee strength declined at a constant rate of 0.57 kg/year. Faster rates of decline in grip and hip strength, but not knee strength, independently predicted mortality after accounting for baseline levels and potential confounders (hazard ratio (HR)=1.33, 95% confidence interval (95% CI)=1.06-1.67, HR=1.14, 95% CI=0.91-1.41, and 2.62, 95% CI=1.43-4.78 for every 0.5 standard deviation increase in rate of decline in grip, knee, and hip strength, respectively). CONCLUSION: Monitoring the rate of decline in grip and hip flexion strength in addition to absolute levels may greatly improve the identification of women most at risk of dying.
AB - OBJECTIVES: To assess the relationship between rate of change in muscle strength and all-cause mortality. DESIGN: Prospective observational study of the causes and course of physical disability. SETTING: Twelve contiguous ZIP code areas in Baltimore, Maryland. PARTICIPANTS: Three hundred seven community-dwelling women aged 70 to 79 at study baseline. MEASUREMENTS: The outcome was all-cause mortality (1994-2009); predictors included up to seven repeated measurements of handgrip, knee extension, and hip flexion strength, with a median follow-up time of 10 years. Demographic factors, body mass index, smoking status, number of chronic diseases, depressive symptoms, physical activity, interleukin-6, and albumin were assessed at baseline and included as confounders. The associations between declining muscle strength and mortality were assessed using a joint longitudinal and survival model. RESULTS: Grip and hip strength declined an average of 1.10 and 1.31 kg/year between age 70 and 75 and 0.50 and 0.39 kg/year thereafter, respectively; knee strength declined at a constant rate of 0.57 kg/year. Faster rates of decline in grip and hip strength, but not knee strength, independently predicted mortality after accounting for baseline levels and potential confounders (hazard ratio (HR)=1.33, 95% confidence interval (95% CI)=1.06-1.67, HR=1.14, 95% CI=0.91-1.41, and 2.62, 95% CI=1.43-4.78 for every 0.5 standard deviation increase in rate of decline in grip, knee, and hip strength, respectively). CONCLUSION: Monitoring the rate of decline in grip and hip flexion strength in addition to absolute levels may greatly improve the identification of women most at risk of dying.
KW - handgrip strength
KW - hip strength
KW - knee strength
KW - mortality
KW - older women
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U2 - 10.1111/j.1532-5415.2010.03154.x
DO - 10.1111/j.1532-5415.2010.03154.x
M3 - Article
C2 - 21054287
AN - SCOPUS:78449313332
SN - 0002-8614
VL - 58
SP - 2076
EP - 2084
JO - Journal of the American Geriatrics Society
JF - Journal of the American Geriatrics Society
IS - 11
ER -