Herpesviruses and lymphoma

Research output: Chapter in Book/Report/Conference proceedingChapter

Abstract

Two herpesviruses (HHV) are associated with lymphoma and lymphoproliferative disease in man: Epstein-Barr virus (EBV) and Kaposi sarcoma-associated herpesvirus (KSHV, also referred to as HHV-8).1 Both were first identified in tumors, both establish latency in B cell reservoirs that are maintained for life, and both are present in saliva.2,3 Primary infection is commonly asymptomatic and most hosts do not develop tumors.4 Immunocompromise appears to be important for the pathogenesis of some but not all of the virus-associated tumors. These similarities notwithstanding, the viruses and their associated lymphoproliferative diseases are quite different: EBV is ubiquitous whereas KSHV shows striking variation in its prevalence among populations; and EBV is associated with many different lymphomas and lymphoproliferative diseases whereas KSHV is associated with only a few. This chapter begins with an overview of the viruses and their associations with malignancies and then focuses on consideration of their associations with lymphoma.

Original languageEnglish (US)
Title of host publicationThe Lymphoid Neoplasms 3ed
PublisherCRC Press
Pages116-125
Number of pages10
ISBN (Electronic)9781444113228
ISBN (Print)9780340809471
DOIs
StatePublished - Jan 1 2010

ASJC Scopus subject areas

  • Medicine(all)

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  • Cite this

    Ambinder, R. F. (2010). Herpesviruses and lymphoma. In The Lymphoid Neoplasms 3ed (pp. 116-125). CRC Press. https://doi.org/10.1201/b13424