Herpesvirus saimiri has a gene specifying a homologue of the cellular membrane glycoprotein CD59

J. C. Albrecht; J. Nicholast; K. R. Cameron; C. Newman; B. Fleckenstein; R. W. Honess

doi:10.1016/0042-6822(92)91247-R

Herpesvirus saimiri has a gene specifying a homologue of the cellular membrane glycoprotein CD59

J. C. Albrecht, J. Nicholast, K. R. Cameron, C. Newman, B. Fleckenstein, R. W. Honess

Research output: Contribution to journal › Article › peer-review

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Abstract

Herpesvirus saimiri (HVS) is a T-lymphotropic tumor virus that causes fulminant lymphomas and leukemias in various New World primates other than its natural host, the squirrel monkey (Saimiri sciureus). In the course of completing the nucleotide sequence of its genome, we identified an open reading frame of 363 nucleotides, designated HVS-15, that has no detectable homology to any other viral sequences to date. HVS-15 encodes a 121-amino-acid protein which shows significant similarities to human CD59, a phosphatidyl-inositol-glycan-anchored glycoprotein involved in T-cell activation and restriction of complement-mediated lysis. The predicted HVS-15 gene product is more similar to human CD59 than to the related murine Ly-6 antigens. A nucleotide sequence identity of 64% was found between HVS-15 and the CD59 reading frame, and a 48% identity exists between the corresponding protein sequences. The comparison of the amino acid sequences revealed a number of conserved structural features such as a similar pattern of hydrophobic termini and an identical cysteine skeleton.

Original language	English (US)
Pages (from-to)	527-530
Number of pages	4
Journal	Virology
Volume	190
Issue number	1
DOIs	https://doi.org/10.1016/0042-6822(92)91247-R
State	Published - Sep 1992
Externally published	Yes

ASJC Scopus subject areas

Virology

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title = "Herpesvirus saimiri has a gene specifying a homologue of the cellular membrane glycoprotein CD59",

abstract = "Herpesvirus saimiri (HVS) is a T-lymphotropic tumor virus that causes fulminant lymphomas and leukemias in various New World primates other than its natural host, the squirrel monkey (Saimiri sciureus). In the course of completing the nucleotide sequence of its genome, we identified an open reading frame of 363 nucleotides, designated HVS-15, that has no detectable homology to any other viral sequences to date. HVS-15 encodes a 121-amino-acid protein which shows significant similarities to human CD59, a phosphatidyl-inositol-glycan-anchored glycoprotein involved in T-cell activation and restriction of complement-mediated lysis. The predicted HVS-15 gene product is more similar to human CD59 than to the related murine Ly-6 antigens. A nucleotide sequence identity of 64% was found between HVS-15 and the CD59 reading frame, and a 48% identity exists between the corresponding protein sequences. The comparison of the amino acid sequences revealed a number of conserved structural features such as a similar pattern of hydrophobic termini and an identical cysteine skeleton.",

author = "Albrecht, {J. C.} and J. Nicholast and Cameron, {K. R.} and C. Newman and B. Fleckenstein and Honess, {R. W.}",

note = "Funding Information: The DNA sequencing work was supported by the Medical Research Council, U.K., and its analysis by the Deutsche Forschungsgemeinschaft, Forschergruppe “DNA-Viren des haematopoetischen Systems.” The nucleotide sequence data will appear in the EMBL, GenBank and DDBJ Nucleotide Sequence Databases under the Accession Number X64273.",

year = "1992",

month = sep,

doi = "10.1016/0042-6822(92)91247-R",

language = "English (US)",

volume = "190",

pages = "527--530",

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T1 - Herpesvirus saimiri has a gene specifying a homologue of the cellular membrane glycoprotein CD59

AU - Albrecht, J. C.

AU - Nicholast, J.

AU - Cameron, K. R.

AU - Newman, C.

AU - Fleckenstein, B.

AU - Honess, R. W.

N1 - Funding Information: The DNA sequencing work was supported by the Medical Research Council, U.K., and its analysis by the Deutsche Forschungsgemeinschaft, Forschergruppe “DNA-Viren des haematopoetischen Systems.” The nucleotide sequence data will appear in the EMBL, GenBank and DDBJ Nucleotide Sequence Databases under the Accession Number X64273.

PY - 1992/9

Y1 - 1992/9

N2 - Herpesvirus saimiri (HVS) is a T-lymphotropic tumor virus that causes fulminant lymphomas and leukemias in various New World primates other than its natural host, the squirrel monkey (Saimiri sciureus). In the course of completing the nucleotide sequence of its genome, we identified an open reading frame of 363 nucleotides, designated HVS-15, that has no detectable homology to any other viral sequences to date. HVS-15 encodes a 121-amino-acid protein which shows significant similarities to human CD59, a phosphatidyl-inositol-glycan-anchored glycoprotein involved in T-cell activation and restriction of complement-mediated lysis. The predicted HVS-15 gene product is more similar to human CD59 than to the related murine Ly-6 antigens. A nucleotide sequence identity of 64% was found between HVS-15 and the CD59 reading frame, and a 48% identity exists between the corresponding protein sequences. The comparison of the amino acid sequences revealed a number of conserved structural features such as a similar pattern of hydrophobic termini and an identical cysteine skeleton.

AB - Herpesvirus saimiri (HVS) is a T-lymphotropic tumor virus that causes fulminant lymphomas and leukemias in various New World primates other than its natural host, the squirrel monkey (Saimiri sciureus). In the course of completing the nucleotide sequence of its genome, we identified an open reading frame of 363 nucleotides, designated HVS-15, that has no detectable homology to any other viral sequences to date. HVS-15 encodes a 121-amino-acid protein which shows significant similarities to human CD59, a phosphatidyl-inositol-glycan-anchored glycoprotein involved in T-cell activation and restriction of complement-mediated lysis. The predicted HVS-15 gene product is more similar to human CD59 than to the related murine Ly-6 antigens. A nucleotide sequence identity of 64% was found between HVS-15 and the CD59 reading frame, and a 48% identity exists between the corresponding protein sequences. The comparison of the amino acid sequences revealed a number of conserved structural features such as a similar pattern of hydrophobic termini and an identical cysteine skeleton.

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Herpesvirus saimiri has a gene specifying a homologue of the cellular membrane glycoprotein CD59

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