Herpesvirus saimiri encodes a functional homolog of the human bcl-2 oncogene

V. E. Nava, E. H.Y. Cheng, M. Veliuona, S. Zou, R. J. Clem, M. L. Mayer, J. M. Hardwick

Research output: Contribution to journalArticle

Abstract

Here we demonstrate that open reading frame 16 (ORF16) of the oncogenic herpesvirus saimiri protects cells from heterologous virus-induced apoptosis. The BH1 and BH2 homology domains are highly conserved in ORF16, and ORF16 heterodimerizes with Bcl-2 family members Bax and Bak. However, ORF16 lacks the core sequence of the conserved BH3 homology domain, suggesting that this region is not essential for anti-apoptotic activity. Conservation of a functional bcl-2 homolog among gammaherpesviruses suggests that inhibition of programmed cell death is important in the biology of these viruses.

Original languageEnglish (US)
Pages (from-to)4118-4122
Number of pages5
JournalJournal of virology
Volume71
Issue number5
DOIs
StatePublished - 1997

ASJC Scopus subject areas

  • Microbiology
  • Immunology
  • Insect Science
  • Virology

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