@article{497a0de6b0da4415b7feeb66d13e260c,
title = "Herpesvirus Infections and Risk of Frailty and Mortality in Older Women: Women's Health and Aging Studies",
abstract = "Objectives: To examine the relationship between herpesvirus infections and mortality and incident frailty risks in community-dwelling older women. Design: Nested prospective cohort study. Setting: Women's Health and Aging Studies I and II. Participants: Community-dwelling older women aged 70 to 79 (n = 633). Measurements: Baseline serum antibody (immunoglobulin G) levels against four herpesviruses (herpes simplex virus types 1 (HSV-1) and 2 (HSV-2), varicella-zoster virus (VZV), 7 Epstein-Barr virus (EBV)), 3-year incident frailty rates, and 5-year mortality. Results: Women seropositive for HSV-1 and HSV-2, but not VZV and EBV, had higher risk of 3-year incident frailty (HSV-1: hazard ratio (HR) = 1.90, 95% confidence interval (CI) = 0.96–3.74; HSV-2: HR = 2.10, 95% CI = 1.05–4.37) and 5-year mortality (HR = 1.73, 95% CI = 0.93–3.20; HR = 1.80, 95% CI = 0.94–3.44, respectively) than seronegative women. Incremental increases in serum HSV-1 and HSV-2 antibody levels were associated with incrementally higher risks of incident frailty and mortality. After adjustment for potential confounders, only higher serum HSV-2 antibody level was independently predictive of higher risk of mortality in older women (for each unit increase in antibody index, HR = 1.47, 95% CI = 1.05–2.07). Conclusion: HSV-1 and HSV-2 antibody levels are not independently associated with risk of incident frailty in older women. Only HSV-2 antibody level is independently predictive of 5-year mortality risk, with each incremental increase in the antibody level adding further risk.",
keywords = "cytomegalovirus, frailty, herpes simplex virus, herpesvirus, mortality",
author = "Wang, {George C.} and Christina Han and Barbara Detrick and Vincenzo Casolaro and Levine, {David M.} and Fried, {Linda P.} and Walston, {Jeremy D.}",
note = "Funding Information: This work was supported by National Institutes of Health, National Institute on Aging Grants K23 AG033113 and P30 AG021334 (through the Johns Hopkins Older Americans Independence Center); the T. Franklin Williams Research Scholars Award, sponsored by the Atlantic Philanthropies, the American Geriatrics Society, the John A. Hartford Foundation, and the Association of Subspecialty Professors; the John A. Hartford Foundation's Center of Excellence in Geriatric Medicine Scholars Award; and the Johns Hopkins Biology of Healthy Aging Program. Conflict of Interest: The authors declare no financial, personal, or other potential conflicts of interest. Author Contributions: Wang: study design, data analysis, writing first draft of manuscript. Han: laboratory assays, data analysis, manuscript preparation. Detrick: data acquisition, study concept, data interpretation. Casolaro: data interpretation, manuscript preparation. Levine: study concept, data interpretation, manuscript preparation. Fried: development of WHAS cohorts, data interpretation, manuscript preparation. Walston: study concept, data interpretation, manuscript preparation. All authors: review and editing of manuscript drafts, approval of final version. Sponsor's Role: The investigators retained full independence in the conduct of this research and report no conflicts of interest. Publisher Copyright: {\textcopyright} 2016, Copyright the Authors Journal compilation {\textcopyright} 2016, The American Geriatrics Society Copyright: Copyright 2017 Elsevier B.V., All rights reserved.",
year = "2016",
month = may,
day = "1",
doi = "10.1111/jgs.14090",
language = "English (US)",
volume = "64",
pages = "998--1005",
journal = "Journal of the American Geriatrics Society",
issn = "0002-8614",
publisher = "Wiley-Blackwell",
number = "5",
}