Herpes zoster infection after autologous bone marrow transplantation

L. M. Schuchter, J. R. Wingard, S. Piantadosi, W. H. Burns, G. W. Santos, R. Saral

    Research output: Contribution to journalArticle

    Abstract

    One hundred fifty-three patients who underwent autologous bone marrow transplant (ABMT) were studied retrospectively to determine the frequency, outcome, and risk-factors associated with varicella-zoster infections (VZV). Forty-three patients (28%) developed VZV infection after transplant. The median onset of infection was the fifth month, with 91% of cases occurring within the first year. Thirty-three patients (77%) had localized herpes zoster, and ten patients (23%) had varicella. Cutaneous dissemination developed in 15% of patients and probable visceral dissemination developed in 5%. Overall morbidity was 25% and included scarring, alopecia, postherpetic neuralgia, and neurologic dysfunction. There were no deaths from VZV infection. The majority of patients (79%) were treated with intravenous (IV) acyclovir. The only significant risk factor associated with VZV infection was the underlying disease. VZV infection occurred most frequently in patients with Hodgkin's and non-Hodgkin's lymphoma (46%) as compared with patients with leukemia (23%) or solid tumors (9%)(P < .002). The frequency of VZV infection in ABMT patients appears to be comparable to that reported for allogeneic BMT patients and other immunocompromised patients.

    Original languageEnglish (US)
    Pages (from-to)1424-1427
    Number of pages4
    JournalBlood
    Volume74
    Issue number4
    DOIs
    StatePublished - 1989

    ASJC Scopus subject areas

    • Biochemistry
    • Immunology
    • Hematology
    • Cell Biology

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  • Cite this

    Schuchter, L. M., Wingard, J. R., Piantadosi, S., Burns, W. H., Santos, G. W., & Saral, R. (1989). Herpes zoster infection after autologous bone marrow transplantation. Blood, 74(4), 1424-1427. https://doi.org/10.1182/blood.v74.4.1424.1424