Herpes Zoster in Children with Cancer

Sandor Feldman, Walter T. Hughes, H. Y. Kim

Research output: Contribution to journalArticle

Abstract

Of 1,132 children treated for malignant neoplasias at St. Jude Children's Research Hospital, 101 developed herpes zoster. This population was studied retrospectively to determine frequency of infection, relationship to cancer therapy, clinical course, complications, and results of treatment. The incidence of infection was highest (22%) in patients with Hodgkin disease and lowest (0.7%) in patients with acute myelogenous leukemia. The overall incidence was 9%. Mortality was low in these children—3% for those with infection and 0.3% for the total population. Complications included pneumonitis, meningoencephalitis, chronic thrombocytopenia, iritis, keratitis, and progressive and prolonged cutaneous zoster. Cobalt-60 irradiation produced no significant changes in zoster incidence, and no specific chemotherapeutic drugs could be implicated as instigating factors in infection. Rates of survival and recurrence of malignant neoplasm were not affected by the presence of herpes zoster infection.

Original languageEnglish (US)
Pages (from-to)178-184
Number of pages7
JournalAmerican Journal of Diseases of Children
Volume126
Issue number2
DOIs
StatePublished - 1973
Externally publishedYes

Fingerprint

Herpes Zoster
Infection
Neoplasms
Incidence
Iritis
Meningoencephalitis
Keratitis
Cobalt
Hodgkin Disease
Acute Myeloid Leukemia
Thrombocytopenia
Population
Pneumonia
Survival Rate
Recurrence
Skin
Mortality
Therapeutics
Research
Pharmaceutical Preparations

ASJC Scopus subject areas

  • Pediatrics, Perinatology, and Child Health

Cite this

Herpes Zoster in Children with Cancer. / Feldman, Sandor; Hughes, Walter T.; Kim, H. Y.

In: American Journal of Diseases of Children, Vol. 126, No. 2, 1973, p. 178-184.

Research output: Contribution to journalArticle

Feldman, Sandor ; Hughes, Walter T. ; Kim, H. Y. / Herpes Zoster in Children with Cancer. In: American Journal of Diseases of Children. 1973 ; Vol. 126, No. 2. pp. 178-184.
@article{0d1b7f894a6d4a14858d11a8dca50ae0,
title = "Herpes Zoster in Children with Cancer",
abstract = "Of 1,132 children treated for malignant neoplasias at St. Jude Children's Research Hospital, 101 developed herpes zoster. This population was studied retrospectively to determine frequency of infection, relationship to cancer therapy, clinical course, complications, and results of treatment. The incidence of infection was highest (22{\%}) in patients with Hodgkin disease and lowest (0.7{\%}) in patients with acute myelogenous leukemia. The overall incidence was 9{\%}. Mortality was low in these children—3{\%} for those with infection and 0.3{\%} for the total population. Complications included pneumonitis, meningoencephalitis, chronic thrombocytopenia, iritis, keratitis, and progressive and prolonged cutaneous zoster. Cobalt-60 irradiation produced no significant changes in zoster incidence, and no specific chemotherapeutic drugs could be implicated as instigating factors in infection. Rates of survival and recurrence of malignant neoplasm were not affected by the presence of herpes zoster infection.",
author = "Sandor Feldman and Hughes, {Walter T.} and Kim, {H. Y.}",
year = "1973",
doi = "10.1001/archpedi.1973.02110190156009",
language = "English (US)",
volume = "126",
pages = "178--184",
journal = "JAMA Pediatrics",
issn = "2168-6203",
publisher = "American Medical Association",
number = "2",

}

TY - JOUR

T1 - Herpes Zoster in Children with Cancer

AU - Feldman, Sandor

AU - Hughes, Walter T.

AU - Kim, H. Y.

PY - 1973

Y1 - 1973

N2 - Of 1,132 children treated for malignant neoplasias at St. Jude Children's Research Hospital, 101 developed herpes zoster. This population was studied retrospectively to determine frequency of infection, relationship to cancer therapy, clinical course, complications, and results of treatment. The incidence of infection was highest (22%) in patients with Hodgkin disease and lowest (0.7%) in patients with acute myelogenous leukemia. The overall incidence was 9%. Mortality was low in these children—3% for those with infection and 0.3% for the total population. Complications included pneumonitis, meningoencephalitis, chronic thrombocytopenia, iritis, keratitis, and progressive and prolonged cutaneous zoster. Cobalt-60 irradiation produced no significant changes in zoster incidence, and no specific chemotherapeutic drugs could be implicated as instigating factors in infection. Rates of survival and recurrence of malignant neoplasm were not affected by the presence of herpes zoster infection.

AB - Of 1,132 children treated for malignant neoplasias at St. Jude Children's Research Hospital, 101 developed herpes zoster. This population was studied retrospectively to determine frequency of infection, relationship to cancer therapy, clinical course, complications, and results of treatment. The incidence of infection was highest (22%) in patients with Hodgkin disease and lowest (0.7%) in patients with acute myelogenous leukemia. The overall incidence was 9%. Mortality was low in these children—3% for those with infection and 0.3% for the total population. Complications included pneumonitis, meningoencephalitis, chronic thrombocytopenia, iritis, keratitis, and progressive and prolonged cutaneous zoster. Cobalt-60 irradiation produced no significant changes in zoster incidence, and no specific chemotherapeutic drugs could be implicated as instigating factors in infection. Rates of survival and recurrence of malignant neoplasm were not affected by the presence of herpes zoster infection.

UR - http://www.scopus.com/inward/record.url?scp=0015653515&partnerID=8YFLogxK

UR - http://www.scopus.com/inward/citedby.url?scp=0015653515&partnerID=8YFLogxK

U2 - 10.1001/archpedi.1973.02110190156009

DO - 10.1001/archpedi.1973.02110190156009

M3 - Article

C2 - 4353308

AN - SCOPUS:0015653515

VL - 126

SP - 178

EP - 184

JO - JAMA Pediatrics

JF - JAMA Pediatrics

SN - 2168-6203

IS - 2

ER -