Herpes Simplex Virus Type 2 Infection, Syphilis, and Hepatitis B Virus Infection in Haitian Women with Human Immunodeficiency Virus Type 1 and Human T Lymphotropic Virus Type I Infections

The Johns Hopkins University (JHU)/Centre pour le Développement et la Santé (CDS) HIV Study Group

Research output: Contribution to journalArticle

Abstract

Antibodies to herpes simplex virus type 2 (HSV-2), antibodies to hepatitis B virus (HBV) core antigen (anti-HBc), and VDRL antibodies (serologic evidence of syphilis) were evaluated in women known to be infected with human immunodeficiency virus type 1 (HIV-1) (n = 95) or human T lymphotropic virus type I (HTLV-I) (n = 45) and controls (n = 89). HIV-l-seropositive women were more likely than controls to have antibodies to HSV-2 (88% vs. 54%; P <.001), anti-HBc (67% vs. 43%; P =.008), and VDRL antibodies (21% vs. 8%; P =.02). Similarly, HTLV-I-seropositive women were more likely than controls to have antibodies to HSV-2 (82% vs. 54%; P =.003) and anti-HBc (67% vs. 43%; P =.008). There was no evidence that HIV-1 or HTLV-I predisposed to chronic hepatitis B virus infection. The stronger associations between HIV-1 and HTLV-I with HSV-2 than the associations with syphilis or HBV are consistent with the hypothesis that recurrent disruptions of mucous membranes caused by HSV-2 infections predispose to sexual transmission of HIV-1 and HTLV-I.

Original languageEnglish (US)
Pages (from-to)418-420
Number of pages3
JournalJournal of Infectious Diseases
Volume166
Issue number2
DOIs
StatePublished - Aug 1992

ASJC Scopus subject areas

  • Immunology and Allergy
  • Infectious Diseases

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