TY - JOUR
T1 - Herpes Simplex Virus Type 1 infection is associated with suicidal behavior and first registered psychiatric diagnosis in a healthy population
AU - Nissen, J.
AU - Trabjerg, Betina
AU - Pedersen, M. G.
AU - Banasik, Karina
AU - Pedersen, Ole Birger
AU - Sørensen, Erik
AU - Nielsen, Kaspar René
AU - Erikstrup, Christian
AU - Petersen, Mikkel Steen
AU - Paarup, Helene Martina
AU - Bruun-Rasmussen, P.
AU - Westergaard, D.
AU - Hansen, T. F.
AU - Pedersen, Carsten B.
AU - Werge, Thomas
AU - Torrey, Fuller
AU - Hjalgrim, Henrik
AU - Mortensen, Preben Bo
AU - Yolken, Robert
AU - Brunak, Søren
AU - Ullum, Henrik
AU - Burgdorf, K. S.
N1 - Funding Information:
This work was supported by The Lundbeck Foundation [R209-2015-3500]; The Danish Administrative Regions ; The Danish Administrative Regions’ Bio- and Genome Bank ; The Novo Nordisk Foundation [NNF14CC0001 and NNF17OC0027594]; and The Stanley Medical Research Institute . The funders had no role in study design, data collection and analysis, decision to publish, or preparation of the manuscript.
Funding Information:
This work was supported by The Lundbeck Foundation [R209-2015-3500]; The Danish Administrative Regions; The Danish Administrative Regions’ Bio- and Genome Bank; The Novo Nordisk Foundation [NNF14CC0001 and NNF17OC0027594]; and The Stanley Medical Research Institute. The funders had no role in study design, data collection and analysis, decision to publish, or preparation of the manuscript. We acknowledge and thank all the Danish blood donors and the staff at the Danish blood donation centers who were involved in the present study. We acknowledge Medical Laboratory Technician Janne Amstrup from the Department of Clinical Immunology 2034, Copenhagen University Hospital for her logistical help with the samples.
Publisher Copyright:
© 2019 The Authors
PY - 2019/10
Y1 - 2019/10
N2 - Increasing evidence shows that latent infections and inflammation is associated with cognitive and behavioral changes in humans. This case-control study investigates the association between Herpes Simplex Virus Type 1 (HSV-1) infection and C-reactive Protein (CRP) levels, and psychiatric disorders and suicidal behavior. Public health register data from 81,912 participants in the Danish Blood Donor Study, were reviewed to identify individuals registered with an ICD-10 code of any psychiatric diagnosis, or who had attempted or committed suicide. We found 1,504 psychiatric cases and 353 suicidal cases; for all cases, controls were frequency-matched by age and sex, resulting in 5,336 participants. Plasma samples were analyzed for IgG-class antibodies against HSV-1 and CRP. HSV-1 infection was associated with suicidal behavior (odds-ratio, 1.40; 95% confidence interval [CI] 1.11–1.77). Accounting for temporality, HSV-1 infection was associated with having first psychiatric disorder after the date of blood collection (incidence rate ration, 1.44; 95% CI, 1.05–1.95). No association between CRP and psychiatric disorders or suicidal behavior was found. The finding that HSV-1 was associated with suicidal behavior and first psychiatric disorder indicates that infection may play a role in the etiology and pathogenesis of suicidal behavior and development of psychiatric disorders.
AB - Increasing evidence shows that latent infections and inflammation is associated with cognitive and behavioral changes in humans. This case-control study investigates the association between Herpes Simplex Virus Type 1 (HSV-1) infection and C-reactive Protein (CRP) levels, and psychiatric disorders and suicidal behavior. Public health register data from 81,912 participants in the Danish Blood Donor Study, were reviewed to identify individuals registered with an ICD-10 code of any psychiatric diagnosis, or who had attempted or committed suicide. We found 1,504 psychiatric cases and 353 suicidal cases; for all cases, controls were frequency-matched by age and sex, resulting in 5,336 participants. Plasma samples were analyzed for IgG-class antibodies against HSV-1 and CRP. HSV-1 infection was associated with suicidal behavior (odds-ratio, 1.40; 95% confidence interval [CI] 1.11–1.77). Accounting for temporality, HSV-1 infection was associated with having first psychiatric disorder after the date of blood collection (incidence rate ration, 1.44; 95% CI, 1.05–1.95). No association between CRP and psychiatric disorders or suicidal behavior was found. The finding that HSV-1 was associated with suicidal behavior and first psychiatric disorder indicates that infection may play a role in the etiology and pathogenesis of suicidal behavior and development of psychiatric disorders.
KW - C-reactive protein
KW - Herpes Simplex Virus type 1
KW - Infection
KW - Inflammation
KW - Psychiatric disorders
KW - Suicide
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U2 - 10.1016/j.psyneuen.2019.06.015
DO - 10.1016/j.psyneuen.2019.06.015
M3 - Article
C2 - 31284079
AN - SCOPUS:85068363073
SN - 0306-4530
VL - 108
SP - 150
EP - 154
JO - Psychoneuroendocrinology
JF - Psychoneuroendocrinology
ER -