TY - JOUR
T1 - Herpes simplex virus DNA identification from aqueous fluid in Fuchs heterochromic iridocyclitis
AU - Barequet, Irina S.
AU - Li, Qian
AU - Wang, Yun
AU - O'Brien, Terrence P.
AU - Hooks, John J.
AU - Stark, Walter J.
N1 - Funding Information:
The work was supported in part by the Helen and Raymond Kwok (Hong Kong) Research Fund.
PY - 2000/5
Y1 - 2000/5
N2 - PURPOSE: To report the presence of herpes simplex virus DNA in the aqueous humor of an eye with Fuchs heterochromic iridocyclitis. METHODS: In an eye with a clinical diagnosis of Fuchs heterochromic iridocyclitis, samples of aqueous humor and anterior capsule of the lens were obtained during cataract surgery. Polymerase chain reaction was performed on the samples to detect the presence of viral DNA including herpes simplex virus, varicella-zoster virus, and cytomegalovirus. Serologic analysis was also performed for antiviral immunoglobulins. RESULTS: Herpes simplex virus DNA was identified in the aqueous humor but not in the anterior capsule. Serum immunoglobulin G was positive for herpes simplex virus, varicella-zoster virus, and cytomegalovirus. CONCLUSIONS: The presence of herpes simplex virus DNA in the aqueous humor of an eye with Fuchs heterochromic iridocyclitis suggests that herpes simplex virus infection may play a role in the pathogenesis of Fuchs heterochromic iridocyclitis. Copyright (C) 2000 Elsevier Science Inc.
AB - PURPOSE: To report the presence of herpes simplex virus DNA in the aqueous humor of an eye with Fuchs heterochromic iridocyclitis. METHODS: In an eye with a clinical diagnosis of Fuchs heterochromic iridocyclitis, samples of aqueous humor and anterior capsule of the lens were obtained during cataract surgery. Polymerase chain reaction was performed on the samples to detect the presence of viral DNA including herpes simplex virus, varicella-zoster virus, and cytomegalovirus. Serologic analysis was also performed for antiviral immunoglobulins. RESULTS: Herpes simplex virus DNA was identified in the aqueous humor but not in the anterior capsule. Serum immunoglobulin G was positive for herpes simplex virus, varicella-zoster virus, and cytomegalovirus. CONCLUSIONS: The presence of herpes simplex virus DNA in the aqueous humor of an eye with Fuchs heterochromic iridocyclitis suggests that herpes simplex virus infection may play a role in the pathogenesis of Fuchs heterochromic iridocyclitis. Copyright (C) 2000 Elsevier Science Inc.
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U2 - 10.1016/S0002-9394(00)00409-8
DO - 10.1016/S0002-9394(00)00409-8
M3 - Article
C2 - 10844066
AN - SCOPUS:0034073118
SN - 0002-9394
VL - 129
SP - 672
EP - 673
JO - American journal of ophthalmology
JF - American journal of ophthalmology
IS - 5
ER -