Herpes simplex encephalitis and bilateral acute retinal necrosis syndrome after craniotomy

Julian D. Perry, Christopher A. Girkin, Neil R Miller, Douglas A. Kerr

Research output: Contribution to journalArticle

Abstract

PURPOSE: Acute retinal necrosis (ARN) syndrome is associated with members of the herpes virus family, but the mechanisms of infection remain unclear. The purpose of this study is to report a unique case of acute retinal necrosis syndrome associated with herpetic encephalitis in order to elucidate possible factors involved in herpetic central nervous system disease. METHOD: Case report. RESULTS: A 64-year-old woman who developed acute herpes simplex virus encephalitis associated with bilateral acute retinal necrosis syndrome after craniotomy for resection of a suprasellar craniopharyngioma is presented. The results of lumbar puncture, magnetic resonance imaging, and ophthalmologic examination are consistent with herpetic infection. The origin of acute retinal necrosis syndrome and the association of acute retinal necrosis syndrome with encephalitis are reviewed. CONCLUSIONS: After craniotomy, we hypothesize reactivation of previously latent herpes simplex virus in the area of the inferior frontal lobe and optic chiasm. Reactivated virus may have migrated to the retina by axonal transport, through the optic nerves, to produce the acute retinal necrosis syndrome.

Original languageEnglish (US)
Pages (from-to)456-460
Number of pages5
JournalAmerican Journal of Ophthalmology
Volume126
Issue number3
DOIs
StatePublished - Sep 1998

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Acute Retinal Necrosis Syndrome
Herpes Simplex Encephalitis
Craniotomy
Simplexvirus
Viruses
Optic Chiasm
Craniopharyngioma
Axonal Transport
Spinal Puncture
Central Nervous System Diseases
Frontal Lobe
Encephalitis
Optic Nerve
Infection
Retina
Magnetic Resonance Imaging

ASJC Scopus subject areas

  • Ophthalmology

Cite this

Herpes simplex encephalitis and bilateral acute retinal necrosis syndrome after craniotomy. / Perry, Julian D.; Girkin, Christopher A.; Miller, Neil R; Kerr, Douglas A.

In: American Journal of Ophthalmology, Vol. 126, No. 3, 09.1998, p. 456-460.

Research output: Contribution to journalArticle

Perry, Julian D. ; Girkin, Christopher A. ; Miller, Neil R ; Kerr, Douglas A. / Herpes simplex encephalitis and bilateral acute retinal necrosis syndrome after craniotomy. In: American Journal of Ophthalmology. 1998 ; Vol. 126, No. 3. pp. 456-460.
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