Heritability of multivariate gray matter measures in schizophrenia

Jessica A. Turner, Vince Daniel Calhoun, Andrew Michael, Theo G M Van Erp, Stefan Ehrlich, Judith M. Segall, Randy L. Gollub, John Csernansky, Steven G. Potkin, Beng Choon Ho, Juan Bustillo, S. Charles Schulz, Lei Wang

Research output: Contribution to journalArticle

Abstract

Structural brain measures are employed as endophenotypes in the search for schizophrenia susceptibility genes. We analyzed two independent structural imaging datasets with voxel-based morphometry and with source-based morphometry, a multivariate, independent components analysis, to determine the stability and heritability of regional gray matter concentration abnormalities in schizophrenia. The samples comprised 209 and 102 patients with schizophrenia and 208 and 96 healthy volunteers, respectively. The second sample additionally included non-ill siblings of participants with and without schizophrenia. A standard voxel-based analysis showed reproducible regional gray matter deficits in the affected participants compared with unrelated, unaffected controls in both datasets: patients showed significant gray matter concentration deficits in cortical frontal, temporal, and insular lobes. Source-based morphometry (SBM) was applied to the gray matter images of the entire sample to determine the effects of diagnosis on networks of covarying structures. The SBM analysis extracted 24 significant sets of covarying regions (components). Four of these components showed significantly lower gray matter concentrations in patients (p

Original languageEnglish (US)
Pages (from-to)324-335
Number of pages12
JournalTwin Research and Human Genetics
Volume15
Issue number3
DOIs
StatePublished - Jun 2012
Externally publishedYes

Fingerprint

Schizophrenia
Endophenotypes
Temporal Lobe
Siblings
Healthy Volunteers
Gray Matter
Brain
Genes
Datasets

Keywords

  • Brain structure
  • Heritability
  • Independent components analysis
  • Schizophrenia

ASJC Scopus subject areas

  • Genetics(clinical)
  • Obstetrics and Gynecology
  • Pediatrics, Perinatology, and Child Health

Cite this

Turner, J. A., Calhoun, V. D., Michael, A., Van Erp, T. G. M., Ehrlich, S., Segall, J. M., ... Wang, L. (2012). Heritability of multivariate gray matter measures in schizophrenia. Twin Research and Human Genetics, 15(3), 324-335. https://doi.org/10.1017/thg.2012.1

Heritability of multivariate gray matter measures in schizophrenia. / Turner, Jessica A.; Calhoun, Vince Daniel; Michael, Andrew; Van Erp, Theo G M; Ehrlich, Stefan; Segall, Judith M.; Gollub, Randy L.; Csernansky, John; Potkin, Steven G.; Ho, Beng Choon; Bustillo, Juan; Schulz, S. Charles; Wang, Lei.

In: Twin Research and Human Genetics, Vol. 15, No. 3, 06.2012, p. 324-335.

Research output: Contribution to journalArticle

Turner, JA, Calhoun, VD, Michael, A, Van Erp, TGM, Ehrlich, S, Segall, JM, Gollub, RL, Csernansky, J, Potkin, SG, Ho, BC, Bustillo, J, Schulz, SC & Wang, L 2012, 'Heritability of multivariate gray matter measures in schizophrenia', Twin Research and Human Genetics, vol. 15, no. 3, pp. 324-335. https://doi.org/10.1017/thg.2012.1
Turner, Jessica A. ; Calhoun, Vince Daniel ; Michael, Andrew ; Van Erp, Theo G M ; Ehrlich, Stefan ; Segall, Judith M. ; Gollub, Randy L. ; Csernansky, John ; Potkin, Steven G. ; Ho, Beng Choon ; Bustillo, Juan ; Schulz, S. Charles ; Wang, Lei. / Heritability of multivariate gray matter measures in schizophrenia. In: Twin Research and Human Genetics. 2012 ; Vol. 15, No. 3. pp. 324-335.
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