Heritability of levels of autoantibodies using the method of plotting regression of offspring on midparent (ROMP)

Ingrid M. Outschoorn, Noel R. Rose, C. Lynne Burek, Tim W. Jones, Ian R. Mackay, Merrill J. Rowley

Research output: Contribution to journalArticle

Abstract

The genetic control of the levels of autoantibodies has rarely been examined. We examined the heritability of autoantibodies to glutamic acid decarboxylase (GAD65) in type 1 diabetes, and to thyroglobulin (Tg) in chronic lymphocytic thyroiditis and thyrotoxicosis, using regression of offspring on midparent (ROMP) methods. Levels of autoantibodies in patients and their parents were significantly correlated in thyrotoxicosis (R2 = 0.569, p = 0.001), consistent with the reported Gm association, but not in chronic lymphocytic thyroiditis or type 1 diabetes. Extension of the procedure to other autoantibody disorders could be informative.

Original languageEnglish (US)
Pages (from-to)325-326
Number of pages2
JournalAutoimmunity
Volume38
Issue number4
DOIs
StatePublished - Jun 1 2005

Keywords

  • Autoantibodies
  • Autoimmune thyroiditis
  • GAD/diabetes
  • Gene environment interactions
  • Heritability
  • Thyroglobulin

ASJC Scopus subject areas

  • Immunology and Allergy
  • Immunology

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  • Cite this

    Outschoorn, I. M., Rose, N. R., Burek, C. L., Jones, T. W., Mackay, I. R., & Rowley, M. J. (2005). Heritability of levels of autoantibodies using the method of plotting regression of offspring on midparent (ROMP). Autoimmunity, 38(4), 325-326. https://doi.org/10.1080/08916930500128248