Heritability of Functional Connectivity in Resting State: Assessment of the Dynamic Mean, Dynamic Variance, and Static Connectivity across Networks

Anita D. Barber, Catherine E. Hegarty, Martin Lindquist, Katherine H. Karlsgodt

Research output: Contribution to journalArticlepeer-review

Abstract

Recent efforts to evaluate the heritability of the brain's functional connectome have predominantly focused on static connectivity. However, evaluating connectivity changes across time can provide valuable insight about the inherent dynamic nature of brain function. Here, the heritability of Human Connectome Project resting-state fMRI data was examined to determine whether there is a genetic basis for dynamic fluctuations in functional connectivity. The dynamic connectivity variance, in addition to the dynamic mean and standard static connectivity, was evaluated. Heritability was estimated using Accelerated Permutation Inference for the ACE (APACE), which models the additive genetic (h2), common environmental (c2), and unique environmental (e2) variance. Heritability was moderate (mean h2: dynamic mean = 0.35, dynamic variance = 0.45, and static = 0.37) and tended to be greater for dynamic variance compared to either dynamic mean or static connectivity. Further, heritability of dynamic variance was reliable across both sessions for several network connections, particularly between higher-order cognitive and visual networks. For both dynamic mean and static connectivity, similar patterns of heritability were found across networks. The findings support the notion that dynamic connectivity is genetically influenced. The flexibility of network connections, not just their strength, is a heritable endophenotype that may predispose trait behavior.

Original languageEnglish (US)
Pages (from-to)2834-2844
Number of pages11
JournalCerebral cortex (New York, N.Y. : 1991)
Volume31
Issue number6
DOIs
StatePublished - May 10 2021

Keywords

  • ACE
  • dynamic connectivity
  • heritability
  • resting state networks
  • static connectivity

ASJC Scopus subject areas

  • Cognitive Neuroscience
  • Cellular and Molecular Neuroscience

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