TY - JOUR
T1 - Heritability of ambulatory and office blood pressure in the Swiss population
AU - Alwan, Heba
AU - Ehret, Georg
AU - Ponte, Belen
AU - Pruijm, Menno
AU - Ackermann, Daniel
AU - Guessous, Idris
AU - Staessen, Jan A.
AU - Asayama, Kei
AU - Kutalik, Zoltán
AU - Vuistiner, Philippe
AU - Paccaud, Fred
AU - Pechere-Bertschi, Antoinette
AU - Mohaupt, Markus
AU - Vogt, Bruno
AU - Martin, Pierre Yves
AU - Burnier, Michel
AU - Bochud, Murielle
N1 - Funding Information:
Funding sources: The study is supported by the Swiss National Science Foundation FN 33CM30–124087 and FN 33CM30–140331, with specific funding for D.A., H.A., G.E., I.G., B.P. and M.P. Some of the results of this study were obtained by using the program package S.A.G.E., which was supported by a US Public Health Service Resource Grant (RR03655) from the National Center for Research Resources.
Publisher Copyright:
© 2015 Wolters Kluwer Health, Inc.
PY - 2015
Y1 - 2015
N2 - Background: Blood pressure (BP) is known to aggregate in families. Yet, heritability estimates are population-specific and no Swiss data have been published so far. We estimated the heritability of ambulatory and office BP in a Swiss population-based sample. Methods: The Swiss Kidney Project on Genes in Hypertension is a population-based family study focusing on BP genetics. Office and ambulatory BP were measured in 1009 individuals from 271 nuclear families. Heritability was estimated for SBP, DBP, and pulse pressure using a maximum likelihood method implanted in the Statistical Analysis in Genetic Epidemiology software. Results: The 518 women and 491 men included in this analysis had a mean (±SD) age of 48.3 (±17.4) and 47.3 (±17.7) years, and a mean BMI of 23.8 (±4.2) and 25.9 (±4.1) kg/m 2, respectively. Narrow-sense heritability estimates (±standard error) for ambulatory SBP, DBP, and pulse pressure were 0.37±0.07, 0.26±0.07, and 0.29±0.07 for 24-h BP; 0.39±0.07, 0.28±0.07, and 0.27±0.07 for day BP; and 0.25±0.07, 0.20±0.07, and 0.30±0.07 for night BP, respectively (all P<0.001). Heritability estimates for office SBP, DBP, and pulse pressure were 0.21±0.08, 0.25±0.08, and 0.18±0.07 (all P<0.01). Conclusions: We found significant heritability estimates for both ambulatory and office BP in this Swiss population-based study. Our findings justify the ongoing search for the genetic determinants of BP.
AB - Background: Blood pressure (BP) is known to aggregate in families. Yet, heritability estimates are population-specific and no Swiss data have been published so far. We estimated the heritability of ambulatory and office BP in a Swiss population-based sample. Methods: The Swiss Kidney Project on Genes in Hypertension is a population-based family study focusing on BP genetics. Office and ambulatory BP were measured in 1009 individuals from 271 nuclear families. Heritability was estimated for SBP, DBP, and pulse pressure using a maximum likelihood method implanted in the Statistical Analysis in Genetic Epidemiology software. Results: The 518 women and 491 men included in this analysis had a mean (±SD) age of 48.3 (±17.4) and 47.3 (±17.7) years, and a mean BMI of 23.8 (±4.2) and 25.9 (±4.1) kg/m 2, respectively. Narrow-sense heritability estimates (±standard error) for ambulatory SBP, DBP, and pulse pressure were 0.37±0.07, 0.26±0.07, and 0.29±0.07 for 24-h BP; 0.39±0.07, 0.28±0.07, and 0.27±0.07 for day BP; and 0.25±0.07, 0.20±0.07, and 0.30±0.07 for night BP, respectively (all P<0.001). Heritability estimates for office SBP, DBP, and pulse pressure were 0.21±0.08, 0.25±0.08, and 0.18±0.07 (all P<0.01). Conclusions: We found significant heritability estimates for both ambulatory and office BP in this Swiss population-based study. Our findings justify the ongoing search for the genetic determinants of BP.
KW - ambulatory blood pressure
KW - cross-sectional
KW - heritability
KW - population
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U2 - 10.1097/HJH.0000000000000681
DO - 10.1097/HJH.0000000000000681
M3 - Article
C2 - 26203966
AN - SCOPUS:84960098692
VL - 33
SP - 2061
EP - 2067
JO - Journal of Hypertension
JF - Journal of Hypertension
SN - 0263-6352
IS - 10
ER -