Heritability analysis of IgG4 antibodies in autoimmune thyroid disease

I. M. Outschoorn, M. V. Talor, C. L. Burek, W. H. Hoffman, N. R. Rose

Research output: Contribution to journalArticle

Abstract

A study of IgG4 autoantibody levels in juvenile thyroid disease patients showed evidence of heritability using the ROMP screening method. These levels increased with time despite the fact that total IgG antibody decreased with time. Evidence of heritability was demonstrated only in patients with high titers of autoantibodies to both thyroglobulin (Tg) and thyroperoxidase (TPO) unlike family members who may show high titers of one or the other and be asymptomatic at the time of sampling. Since high and low IgG4 levels give different heritability plots, these findings may represent a more severe fibrotic form of thyroiditis with a distinct genetic background. Hence a simple predictive approach is offered by this screening tool for the disease in patients and family members which may be helpful in the future to identify IgG4-related thyroiditis early in the course of disease without the requirement for biopsy.

Original languageEnglish (US)
Pages (from-to)320-326
Number of pages7
JournalAutoimmunity
Volume47
Issue number5
DOIs
StatePublished - Aug 2014

Keywords

  • Autoimmune thyroid disease
  • Autoimmunity genetics
  • Heritability
  • IgG4 related thyroid disease
  • ROMP plots

ASJC Scopus subject areas

  • Immunology and Allergy
  • Immunology

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  • Cite this

    Outschoorn, I. M., Talor, M. V., Burek, C. L., Hoffman, W. H., & Rose, N. R. (2014). Heritability analysis of IgG4 antibodies in autoimmune thyroid disease. Autoimmunity, 47(5), 320-326. https://doi.org/10.3109/08916934.2014.897331