HERG channel function: Beyond long QT

Joseph J. Babcock; Min Li

doi:10.1038/aps.2013.6

HERG channel function: Beyond long QT

Joseph J. Babcock, Min Li

Research output: Contribution to journal › Review article › peer-review

47 Scopus citations

Abstract

To date, research on the human ether-a-go-go related gene (hERG) has focused on this potassium channel's role in cardiac repolarization and Long QT Syndrome (LQTS). However, growing evidence implicates hERG in a diversity of physiologic and pathological processes. Here we discuss these other functions of hERG, particularly their impact on diseases beyond cardiac arrhythmia.

Original language	English (US)
Pages (from-to)	329-335
Number of pages	7
Journal	Acta Pharmacologica Sinica
Volume	34
Issue number	3
DOIs	https://doi.org/10.1038/aps.2013.6
State	Published - Mar 2013
Externally published	Yes

Keywords

cancer
cardiotoxicity
hERG
long QT
potassium channel

ASJC Scopus subject areas

Pharmacology
Pharmacology (medical)

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10.1038/aps.2013.6

Cite this

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abstract = "To date, research on the human ether-a-go-go related gene (hERG) has focused on this potassium channel's role in cardiac repolarization and Long QT Syndrome (LQTS). However, growing evidence implicates hERG in a diversity of physiologic and pathological processes. Here we discuss these other functions of hERG, particularly their impact on diseases beyond cardiac arrhythmia.",

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AB - To date, research on the human ether-a-go-go related gene (hERG) has focused on this potassium channel's role in cardiac repolarization and Long QT Syndrome (LQTS). However, growing evidence implicates hERG in a diversity of physiologic and pathological processes. Here we discuss these other functions of hERG, particularly their impact on diseases beyond cardiac arrhythmia.

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KW - cardiotoxicity

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KW - potassium channel

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HERG channel function: Beyond long QT

Abstract

Keywords

ASJC Scopus subject areas

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