Hereditary prostate cancer in African American families: Linkage analysis using markers that map to five candidate susceptibility loci

W. M. Brown, E. M. Lange, H. Chen, S. L. Zheng, B. Chang, K. E. Wiley, S. D. Isaacs, Patrick Walsh, William B Isaacs, J. Xu, K. A. Cooney

Research output: Contribution to journalArticle

Abstract

African American men have the highest incidence of prostate cancer in the world. Despite this statistic, linkage studies designed to localise prostate cancer susceptibility alleles have included primarily men of Caucasian descent. In this report, we performed a linkage analysis using 33 African American prostate cancer families from two independent research groups. In total, 126 individuals (including 89 men with prostate cancer) were genotyped using markers that map to five prostate cancer susceptibility loci, namely HPC1 at 1q24-25, PCAP at 1q42.2-43, CAPB at 1p36, HPC20 on chromosome 20, and HPCX at Xq27-28. Multipoint mode-of-inheritance-free linkage analyses were performed using the GENEHUNTER software. Some evidence of prostate cancer was detected to HPC1 using all families with a maximum NPL Z score of 1.12 near marker DIS413 (P = 0.13). Increased evidence of linkage was observed in the 24 families with prostate cancer diagnosis prior to age 65 years and in the 20 families with male-to-male transmission. Some evidence of prostate cancer linkage was also detected at markers mapping to PCAP, HPC20, and HPCX. Continued collection and analysis of African American prostate cancer families will lead to an improved understanding of inherited susceptibility in this high-risk group.

Original languageEnglish (US)
Pages (from-to)510-514
Number of pages5
JournalBritish Journal of Cancer
Volume90
Issue number2
DOIs
StatePublished - Jan 26 2004

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Keywords

  • Hereditary cancer syndromes
  • Linkage analysis
  • Prostate cancer

ASJC Scopus subject areas

  • Cancer Research
  • Oncology

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