Hereditary Colorectal Cancer: Genetics and Screening

Lodewijk A.A. Brosens, G. Johan A. Offerhaus, Francis M. Giardiello

Research output: Contribution to journalReview articlepeer-review


Colorectal cancer (CRC) is the third most common cancer and the third leading cause of cancer death in men and women in the United States. About 30% of patients with CRC report a family history of CRC. However, only 5% of CRCs arise in the setting of a well-established mendelian inherited disorder. In addition, serrated polyposis is a clinically defined syndrome with multiple serrated polyps in the colorectum and an increased CRC risk for which the genetics are unknown. This article focuses on genetic and clinical aspects of Lynch syndrome, familial adenomatous polyposis, and MUTYH-associated polyposis.

Original languageEnglish (US)
Pages (from-to)1067-1080
Number of pages14
JournalSurgical Clinics of North America
Issue number5
StatePublished - Oct 1 2015


  • Colorectal cancer
  • Familial adenomatous polyposis
  • Hereditary nonpolyposis colorectal cancer
  • Lynch syndrome
  • MUTYH-associated polyposis

ASJC Scopus subject areas

  • Surgery


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