Hereditary angioneurotic edema: Two genetic variants

Fred S. Rosen; Patricia Charache; Jack Pensky; Virginia Donaldson

doi:10.1126/science.148.3672.957

Hereditary angioneurotic edema: Two genetic variants

Fred S. Rosen, Patricia Charache, Jack Pensky, Virginia Donaldson

School of Medicine

Research output: Contribution to journal › Article › peer-review

276 Scopus citations

Abstract

Serums of patients with hereditary angioneurotic edema lack inhibitory activity against the esterase derived from the first component of complement. In one group of patients this lack appears to result from failure to synthesize the esterase inhibitor of the first component of complement, whereas in another group of patients an abnormal, nonfunctional protein is synthesized.

Original language	English (US)
Pages (from-to)	957-958
Number of pages	2
Journal	Science
Volume	148
Issue number	3672
DOIs	https://doi.org/10.1126/science.148.3672.957
State	Published - Jan 1 1965

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title = "Hereditary angioneurotic edema: Two genetic variants",

abstract = "Serums of patients with hereditary angioneurotic edema lack inhibitory activity against the esterase derived from the first component of complement. In one group of patients this lack appears to result from failure to synthesize the esterase inhibitor of the first component of complement, whereas in another group of patients an abnormal, nonfunctional protein is synthesized.",

author = "Rosen, {Fred S.} and Patricia Charache and Jack Pensky and Virginia Donaldson",

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Hereditary angioneurotic edema: Two genetic variants

Abstract

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