Herd protection by a bivalent killed whole-cell oral cholera vaccine in the slums of Kolkata, India

Mohammad Ali, Dipika Sur, Young Ae You, Suman Kanungo, Binod Sah, Byomkesh Manna, Mahesh Puri, Thomas F. Wierzba, Allan Donner, G. Balakrish Nair, Sujit K. Bhattacharya, Mandeep Singh Dhingra, Jacqueline L. Deen, Anna Lena Lopez, John Clemens

Research output: Contribution to journalArticlepeer-review

Abstract

Background. We evaluated the herd protection conferred by an oral cholera vaccine using 2 approaches: cluster design and geographic information system (GIS) design.Methods. Residents living in 3933 dwellings (clusters) in Kolkata, India, were cluster-randomized to receive either cholera vaccine or oral placebo. Nonpregnant residents aged ≥1 year were invited to participate in the trial. Only the first episode of cholera detected for a subject between 14 and 1095 days after a second dose was considered. In the cluster design, indirect protection was assessed by comparing the incidence of cholera among nonparticipants in vaccine clusters vs those in placebo clusters. In the GIS analysis, herd protection was assessed by evaluating association between vaccine coverage among the population residing within 250 m of the household and the occurrence of cholera in that population.Results. Among 107 347 eligible residents, 66 990 received 2 doses of either cholera vaccine or placebo. In the cluster design, the 3-year data showed significant total protection (66% protection, 95% confidence interval [CI], 50%-78%, P <. 01) but no evidence of indirect protection. With the GIS approach, the risk of cholera among placebo recipients was inversely related to neighborhood-level vaccine coverage, and the trend was highly significant (P <. 01). This relationship held in multivariable models that also controlled for potentially confounding demographic variables (hazard ratio, 0.94 [95% CI,. 90-.98]; P <. 01).Conclusions. Indirect protection was evident in analyses using the GIS approach but not the cluster design approach, likely owing to considerable transmission of cholera between clusters, which would vitiate herd protection in the cluster analyses.

Original languageEnglish (US)
Pages (from-to)1123-1131
Number of pages9
JournalClinical Infectious Diseases
Volume56
Issue number8
DOIs
StatePublished - Apr 15 2013

Keywords

  • bivalent killed oral cholera vaccine
  • cholera
  • cluster randomized trial
  • herd effect

ASJC Scopus subject areas

  • Microbiology (medical)
  • Infectious Diseases

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