Herbal medicines in the management of urolithiasis: Alternative or complementary?

Veronika Butterweck, Saeed R. Khan

Research output: Contribution to journalArticlepeer-review

Abstract

Kidney stone formation or urolithiasis is a complex process that results from a succession of several physicochemical events including supersaturation, nucleation, growth, aggregation, and retention within the kidneys. Epidemiological data have shown that calcium oxalate is the predominant mineral in a majority of kidney stones. Among the treatments used are extracorporeal shock wave lithotripsy (ESWL) and drug treatment. Even improved and besides the high cost that imposes, compelling data now suggest that exposure to shock waves in therapeutic doses may cause acute renal injury, decrease in renal function and an increase in stone recurrence. In addition, persistent residual stone fragments and the possibility of infection after ESWL represent a serious problem in the treatment of stones. Furthermore, in spite of substantial progress in the study of the biological and physical manifestations of kidney stones, there is no satisfactory drug to use in clinical therapy. Data from in vitro, in vivo and clinical trials reveal that phytotherapeutic agents could be useful as either an alternative or an adjunctive therapy in the management of urolithiasis. The present review therefore critically evaluates the potential usefulness of herbal medicines in the management of urolithiasis.

Original languageEnglish (US)
Pages (from-to)1095-1103
Number of pages9
JournalPlanta Medica
Volume75
Issue number10
DOIs
StatePublished - 2009
Externally publishedYes

Keywords

  • Alternative medicine
  • Calcium oxalate
  • Citrates
  • Complementary medicine
  • Kidney stones
  • Nephrolithiasis
  • Oxalates
  • Plant extracts
  • Urolithiasis

ASJC Scopus subject areas

  • Complementary and alternative medicine
  • Molecular Medicine
  • Organic Chemistry
  • Analytical Chemistry
  • Pharmaceutical Science
  • Pharmacology
  • Drug Discovery

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